Successful treatment of acute hepatitis A-associated hemophagocytic syndrome by intravenous immunoglobulin
Journal
Journal of the Formosan Medical Association
Journal Volume
104
Journal Issue
7
Pages
507-510
Date Issued
2005
Author(s)
Abstract
Virus-associated hemophagocytic syndrome (VAHS) is a rare complication in acute hepatitis A virus (HAV) infection. There is no standard therapy for VAHS and the clinical course is variable. Data on the use of intravenous immunoglobulin (IVIG) in the treatment of HAV-associated VAHS is limited. We report a previously healthy, 32-year-old man who presented with general malaise, fever, chills and splenomegaly. Laboratory examination showed marked elevation of aminotransferase, leukopenia and thrombocytopenia. Acute hepatitis A was documented by the presence of immunoglobulin M anti-HAV and compatible liver biopsy findings. Bone marrow examination revealed extensive hemophagocytosis, IVIG was administered after the diagnosis of HAV-associated VAHS. His symptoms and laboratory abnormalities improved, and following a smooth recovery he was discharged 1 month after admission.
SDGs
Other Subjects
aminotransferase; hepatitis A antibody; immunoglobulin M; immunoglobulin; acute hepatitis; adult; aminotransferase blood level; article; bone marrow examination; case report; chill; clinical feature; convalescence; disease association; erythrophagocytosis; fever; hemophagocytic syndrome; hepatitis A; human; human tissue; laboratory test; leukopenia; liver biopsy; malaise; male; splenomegaly; thrombocytopenia; treatment outcome; acute disease; hepatitis A; histiocytosis; Acute Disease; Adult; Hepatitis A; Histiocytosis, Non-Langerhans-Cell; Humans; Immunoglobulins, Intravenous; Male
Type
journal article