https://scholars.lib.ntu.edu.tw/handle/123456789/538418
標題: | Correlation between pulmonary vascular change and hemodynamics in patients with complete atrioventricular septal defect | 作者: | Wu C.-S. ING-SH CHIU Wu S.-J. How S.-W. Chen M.-R. JOU-KOU WANG MEI-HWAN WU |
公開日期: | 2005 | 卷: | 104 | 期: | 2 | 起(迄)頁: | 82-88 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and Purpose: The study of the pulmonary vasculature in Taiwanese with atrioventricular septal defect has not been reported previously. This study investigated the correlation between pulmonary vascular change and hemodynamics in these patients. Methods: Ten children with complete atrioventricular defect, 8 of whom had Down syndrome, underwent open lung biopsy. Their age ranged from 8 months to 6 years (mean, 2 years 7 months). Cardiac catheterization was performed and the systolic pressures of pulmonary and systemic arteries were measured immediately before cardiopulmonary bypass (CPB) and immediately after cardiac repair in 9 patients, and expressed as a ratio of pulmonary to systemic systolic pressure (Pp/Ps). Results: Medial hypertrophy and intimal proliferation were prominent in 7 patients with pulmonary hypertension. The alveolar wall muscular arteries and percent arterial medial thickness increased significandy with increasing post-repair Pp/Ps, preoperative Pp/Ps, pulmonary arteriolar resistance index and pre-CPB Pp/Ps (p < 0.02). The arteries present per 100 alveoli were inversely correlated with the above mentioned hemodynamic parameters (p < 0.02). Conclusions: The results of qualitative and quantitative analyses of the pulmonary vasculature in patients with complete atrioventricular defect correlated well with pre-and postoperative pulmonary arterial pressure and can be used to predict the postoperative pulmonary arterial pressure. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-20144371192&partnerID=40&md5=f69429e7860ec02be6edb36d880a7277 https://scholars.lib.ntu.edu.tw/handle/123456789/538418 |
ISSN: | 0929-6646 | SDG/關鍵字: | article; cardiopulmonary bypass; clinical article; complete atrioventricular septal defect; controlled study; disease association; echocardiography; female; heart atrium septum defect; heart catheterization; heart left right shunt; heart output; heart ventricle septum defect; hemodynamics; human; infant; lung artery pressure; lung biopsy; lung blood vessel; male; morphology; morphometrics; open heart surgery; preschool child; systolic blood pressure; Taiwan; biopsy; child; heart septum defect; hypertrophy; lung; pathology; vascularization; Biopsy; Child; Child, Preschool; Female; Heart Septal Defects, Ventricular; Hemodynamic Processes; Humans; Hypertrophy; Infant; Lung; Male |
顯示於: | 醫學系 |
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