Association between Ataxia Telangiectasia Mutated gene polymorphisms and childhood leukemia in Taiwan
Journal
Chinese Journal of Physiology
Journal Volume
54
Journal Issue
6
Pages
413-418
Date Issued
2011
Author(s)
Abstract
The ataxia telangiectasia mutated (ATM) gene plays a major role in repairing the double-strand breaks and maintaining the genome stability. In this case-control study, associations of seven ATM single-nucleotide polymorphisms (rs600931, rs189037, rs652311, rs624366, rs228589, rs227092 and rs227060) with risks in childhood leukemia in a Taiwanese population were investigated. Two hundred and sixty-six patients with childhood leukemia and 266 age-matched healthy controls recruited were genotyped and analyzed. The P-values of the distributions of the genotypic frequencies in the seven ATM polymorphisms were 0.8925, 0.2835, 0.5772, 0.8731, 0.3641, 0.9181 and 0.5071, respectively. The Pvalues of the distributions of the allelic frequencies in the seven ATM polymorphisms were 0.6158, 0.1179, 0.6971, 0.7944, 0.1887, 0.6605 and 0.2747, respectively. Although the results did not indicate that ATM polymorphism is directly associated with childhood leukemia, the gene-gene and gene-environment interactions of ATM with other factors is worthy of further investigation in the future. ? 2011 by The Chinese Physiological Society and Airiti Press Inc.
Subjects
Ataxia telangiectasia mutated; Childhood leukemia; Polymorphism
SDGs
Other Subjects
adult; article; ataxia telangiectasia mutated gene; child; child health; childhood leukemia; controlled study; disease association; female; gene expression regulation; gene frequency; gene function; gene location; genetic association; genetic risk; genetic susceptibility; genetic variability; genotype environment interaction; human; major clinical study; male; mutational analysis; mutator gene; school child; single nucleotide polymorphism; Taiwan
Publisher
Chinese Physiological Society
Type
journal article