https://scholars.lib.ntu.edu.tw/handle/123456789/538774
標題: | Leukapheresis and cranial irradiation in patients with hyperleukocytic acute myeloid leukemia: No impact on early mortality and intracranial hemorrhage | 作者: | Chang M.-C. Chen T.-Y. JIH-LUH TANG Lan Y.-J. Chao T.-Y. Chiu C.-F. Ho H.-T. |
公開日期: | 2007 | 卷: | 82 | 期: | 11 | 起(迄)頁: | 976-980 | 來源出版物: | American Journal of Hematology | 摘要: | To assess the role of leukapheresis and cranial irradiation in reducing the incidence of intracranial hemorrhage (ICH) and early death in patients with hyperleukocytic acute myeloid leukemia (AML) and the impact of such treatment on survival. This study retrospectively analyzed the records of 75 patients with hyperleukocytic AML who had a white cell count over 100,000/μL. All patients had de novo AML except for two with therapy-related AML. Various factors were assessed for their impact on morbidity and mortality, particularly the role of pre-induction leukapharesis and cranial irradiation. The most significant risk factors for ICH were the presence of two or more symptoms of leukostasis (odds ratios [OR] 10.6, 95% Cl: 2.67-42.02; P = 0.001) and respiratory distress (OR 5.41, 95% CI: 1.44-20.32, P = 0.012). The most significant risk factors for early death were age ? 65 (OR 4.21, 95% CI: 1.45-12.21, P = 0.008), respiratory failure (OR 3.34, 95% CI: 1.24-9.50, P = 0.018), and two or more symptoms (OR 3.50 95% CI: 1.16-10.52, P = 0.026). Neither leukapheresis nor cranial irradiation were significantly associated with a decreased incidence of ICH (P = 0.349 and 0.378, respectively). Leukapheresis had no significant influence on early death (P = 0.367). The median survival patients receiving no pretreatment was 10.50 months (range 2.58-18.42) and for those receiving pretreatment 1.50 months (range 0.10-3.16; log-rank test, P = 0.062). Leukapheresis and cranial irradiation do not improve survival or decrease the incidence of ICH in adults with hyperleukocytic AML. ? 2007 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-35548957852&doi=10.1002%2fajh.20939&partnerID=40&md5=e4c6517420627c89f591de7f4390d984 https://scholars.lib.ntu.edu.tw/handle/123456789/538774 |
ISSN: | 0361-8609 | DOI: | 10.1002/ajh.20939 | SDG/關鍵字: | acute granulocytic leukemia; adult; aged; article; brain hemorrhage; cancer patient; clinical article; controlled study; disease association; female; human; incidence; leukapheresis; leukocyte count; leukostasis; major clinical study; male; morbidity; mortality; priority journal; respiratory distress; retrospective study; risk factor; skull irradiation; survival; symptomatology; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Humans; Intracranial Hemorrhages; Kaplan-Meiers Estimate; Leukapheresis; Leukemia, Myeloid, Acute; Leukocyte Count; Leukostasis; Male; Middle Aged; Respiratory Insufficiency; Retrospective Studies; Treatment Outcome |
顯示於: | 醫學系 |
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