https://scholars.lib.ntu.edu.tw/handle/123456789/538830
標題: | P53 mutation in advanced stage of primary myelodysplastic syndrome | 作者: | JIH-LUH TANG HWEI-FANG TIEN Lin M.-T. PEI-JER CHEN YAO-CHANG CHEN |
公開日期: | 1998 | 出版社: | International Institute of Anticancer Research | 卷: | 18 | 期: | 5 B | 起(迄)頁: | 3757-3761 | 來源出版物: | Anticancer Research | 摘要: | Polymerase chain reaction and single strand conformation polymorphism (PCR-SSCP) analysis of the p53 tumor suppressor gene (from exon 2 to 9) was performed on samples from 47 adult patients with primary myelodysplastic syndrome (MDS). Point mutation was found in 5 (11%) patients: exon 7 in 3, exon 4 in 1 and intron 5 in 1. The frequency of p53 mutation was significantly higher at advanced stages (p = 0.048) and higher in patients with abnormal karyotypes (p = 0.023). Although all of the p53 mutations were detected at advanced stages, four of them were detected at initial diagnosis with very short survival. Sequential SSCP analysis in 20 transformed MDS patients revealed only one new p53 mutation during progression from early MDS phases. The results suggest that p53 mutation might occur as an early genetic event and is probably associated with rapid progression and poor survival in some MDS patients. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984571820&partnerID=40&md5=66b388cfb6e9b149bb471bcc85f5a10b https://scholars.lib.ntu.edu.tw/handle/123456789/538830 |
ISSN: | 0250-7005 | SDG/關鍵字: | protein p53; adult; aged; article; cancer survival; clinical article; exon; female; gene mutation; human; intron; karyotype; male; mutation rate; myelodysplastic syndrome; nucleotide sequence; point mutation; polymerase chain reaction; priority journal; single strand conformation polymorphism; tumor suppressor gene |
顯示於: | 醫學系 |
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