https://scholars.lib.ntu.edu.tw/handle/123456789/539336
標題: | Enthesitis-related arthritis is the most common category of juvenile idiopathic arthritis in Taiwan and presents persistent active disease | 作者: | Shih Y.-J. YAO-HSU YANG Lin C.-Y. Chang C.-L. BOR-LUEN CHIANG |
公開日期: | 2019 | 出版社: | BioMed Central Ltd. | 卷: | 17 | 期: | 1 | 起(迄)頁: | 58 | 來源出版物: | Pediatric Rheumatology | 摘要: | Background: Juvenile idiopathic arthritis (JIA) has been categorized into seven different categories according to the International League of Associations for Rheumatology (ILAR) criteria. Enthesitis-related arthritis (ERA) was found to represent the largest category in a Taiwanese cohort study. The aim in this study was to compare the clinical characteristics, treatments, and outcomes of ERA in a single tertiary center in Taiwan, as compared to those of other categories of JIA. Furthermore, we determined patients' characteristics and risk factors that can help assess the outcomes in ERA. Methods: A retrospective chart review of all patients with JIA referred to a pediatric rheumatology clinic in the National Taiwan University Hospital between 1993 and 2018 were identified according to ILAR criteria. Outcomes were assessed based on the Wallace criteria to categorize patients into active and non-active, including inactive, remission on medication, and remission off medication, groups. A subset of samples was further tested by DNA sequencing to identify HLA-B27 subtypes. Results: One-hundred and eighty-three patients were included in the study, with a mean of 8 years' follow-up. ERA was the single largest category of JIA (39.9%); psoriasis and undifferentiated JIA were both the least common type (0.5%). ERA was male predominant (86%), had a late age of onset (11.0 ± 3.2 years), and the majority of ERA patients was HLA-B27-positive (97%). Of 25 HLA-B27-positive ERA patients checked by HLA-B27 sequencing, 23 were B?27:04 and 2 were B?27:05. ERA patients were significantly less likely to achieve non-active status compared to patients with persistent oligoarthritis (P = 0.036). In terms of treatment response to TNF-α inhibitors in methotrexate-refractory ERA, 26 patients remained active and only 11 patients (30%) achieved a non-active status. Sacroiliitis was a risk factor contributing to poorer treatment response in ERA (P = 0.006). Conclusion: ERA represented the most common category of JIA in Taiwan. Those ERA patients with sacroiliitis were likely to have persistent active disease and may require a more aggressive treatment strategy to improve their outcomes. ? 2019 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071497223&doi=10.1186%2fs12969-019-0363-0&partnerID=40&md5=0567e90fea0f9496df6d8bb4d19404f4 https://scholars.lib.ntu.edu.tw/handle/123456789/539336 |
ISSN: | 1546-0096 | DOI: | 10.1186/s12969-019-0363-0 | SDG/關鍵字: | DNA; HLA B27 antigen; methotrexate; nonsteroid antiinflammatory agent; salazosulfapyridine; steroid; tocilizumab; tumor necrosis factor inhibitor; antirheumatic agent; HLA B27 antigen; adolescent; Article; child; clinical feature; clinical outcome; controlled study; DNA sequence; enthesitis related arthritis; enthesitis related arthritis; female; follow up; human; juvenile rheumatoid arthritis; major clinical study; male; onset age; outcome assessment; priority journal; prognosis; psoriasis; retrospective study; risk factor; sacroiliitis; sex difference; systemic juvenile idiopathic arthritis; Taiwan; treatment response; uveitis; juvenile rheumatoid arthritis; metabolism; sacroiliitis; tertiary care center; treatment outcome; Adolescent; Antirheumatic Agents; Arthritis, Juvenile; Child; Female; Follow-Up Studies; HLA-B27 Antigen; Humans; Male; Retrospective Studies; Risk Factors; Sacroiliitis; Taiwan; Tertiary Care Centers; Treatment Outcome |
顯示於: | 醫學系 |
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