https://scholars.lib.ntu.edu.tw/handle/123456789/539716
Title: | Higher peripheral neutrophil and monocyte counts are independent indicators of the presence and severity of proteinuria in apparently normal adults | Authors: | ZEI-SHUNG HUANG YUNG-MING CHEN KWAN-DUN WU MING-FONG CHEN |
Issue Date: | 2010 | Journal Volume: | 40 | Journal Issue: | 1 | Start page/Pages: | 30-36 | Source: | Internal Medicine Journal | Abstract: | Background: Proteinuria reflects disrupted renal function in which enhanced immuno-inflammation activity plays a key role. So far, information concerning the relations between proteinuria and peripheral different leucocyte counts is limited. We thereby conducted this study aiming to obtain comprehensive information of the issue. Methods: Study subjects were participants of a health check programme from 2000 to 2002. Additional two enrolment criteria were (i) leucocyte analysis was checked with a same blood cell counter and (ii) urinalysis showed no pyuria or haematuria. Data of subjects were retrospectively collected and analysed by using sas program. Results: Higher neutrophil and monocyte counts, but not lymphocyte count, were significantly associated with both the presence and the severity of proteinuria (all P < 0.0001, n = 12 225). Such associations maintained significant after adjustments of age, sex, body mass index, mean blood pressure and blood levels of glycosylated hemoglobin (HbA1c), total cholesterol, triglycerides and creatinine (all P ? 0.001, n = 12 225). There was a sharp increase in the incidence of proteinuria in association with a neutrophil count ?4.50 × 109/L (P ? 0.0001). Conclusion: Our study showed that in apparently normal adults the presence and the severity of proteinuria could be reflected by the peripheral neutrophil and monocyte counts, but not the lymphocyte count. These findings, together with the documented inflammatory basis of proteinuria and the diverse pathophysiological roles of differential leucocytes, suggest that peripheral differential leucocyte counting may be useful in predicting the course of an existing proteinuria. Perspective longitudinal follow-up studies are needed to test this presumption. ? 2010 Royal Australasian College of Physicians. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-76749168082&doi=10.1111%2fj.1445-5994.2008.01881.x&partnerID=40&md5=d891937f86de9a7a1fec0dbb960a125b https://scholars.lib.ntu.edu.tw/handle/123456789/539716 |
ISSN: | 1444-0903 | DOI: | 10.1111/j.1445-5994.2008.01881.x | SDG/Keyword: | cholesterol; creatinine; hemoglobin A1c; triacylglycerol; article; blood cell count; body mass; cholesterol blood level; clinical indicator; creatinine blood level; demography; disease association; disease severity; follow up; health program; human; incidence; leukocyte count; lymphocyte count; major clinical study; mean arterial pressure; monocyte; neutrophil; pathophysiology; priority journal; proteinuria; retrospective study; triacylglycerol blood level; urinalysis; Adult; Female; Humans; Leukocyte Count; Male; Monocytes; Neutrophils; Proteinuria; Retrospective Studies; Severity of Illness Index |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.