https://scholars.lib.ntu.edu.tw/handle/123456789/539720
標題: | Peripheral differential leukocyte counts and subsequent mortality from all diseases, cancers, and cardiovascular diseases in Taiwanese | 作者: | ZEI-SHUNG HUANG KUO-LIONG CHIEN Yang C.-Y. Wang C.-H. TIEN-CHUN CHANG Chen C.-J. |
公開日期: | 2003 | 卷: | 102 | 期: | 11 | 起(迄)頁: | 775-781 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and Purpose: A higher total leukocyte count has been reported to predict all-cause mortality in men, but data are limited for this relation in women and for the relation between differential leukocyte counts and all-cause mortality in both men and women. This study was designed to analyze these relationships in Taiwanese. Methods: A total of 8447 subjects were enrolled from participants in a physical check-up program at National Taiwan University Hospital from 1995 to 1997. Information on mortality was obtained from a national mortality databank that was updated to the end of 2001. Data were analyzed by Student's t test and Cox regression analysis. Results: Among the 245 deaths, 88 were due to cancer and 62 were due to cardiovascular disease. Cox regression analysis revealed an inverse association between lymphocyte count and all-cause mortality in the study group as a whole (all subjects, p<0.01, hazard ratio = 0.73). This inverse association was mainly due to an inverse association between lymphocyte count and cancer mortality (p<0.05, hazard ratio = 0.64), especially the mortality from hepatoma (p = 0.010, hazard ratio = 0.29). The latter hazard ratio of 0.29 indicates that, in all subjects, every decrease of 1.0 × 109/L in lymphocyte count increased the risk of mortality from hepatoma by 3.45-fold during an average follow-up period of 65.5 months. There was a positive association between total leukocyte count and all-cause mortality in men (p < 0.05, hazard ratio = 1.10), mainly due to both the neutrophil and monocyte counts having positive associations with the cardiovascular mortality (both p < 0.05, hazard ratio = 1.23 and 1.22, respectively. The latter hazard ratio of 1.22 indicates that, in men, every increased of 0.1 × 109/L in monocyte count increased the risk of cardiovascular mortality by 1.22-fold. Conclusions: In Taiwanese adults of both genders, a lower lymphocyte counts is associated with cancer mortality, especially mortality from hepatoma. In Taiwanese men, higher neutrophil and monocyte counts are associated with cardiovascular mortality. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-1342285091&partnerID=40&md5=3f9fd73057e5e082d811b324ad8687a7 https://scholars.lib.ntu.edu.tw/handle/123456789/539720 |
ISSN: | 0929-6646 | SDG/關鍵字: | adult; aged; article; cancer; cancer mortality; cancer risk; cardiovascular disease; cardiovascular risk; cause of death; controlled study; data analysis; disease association; female; follow up; human; leukocyte differential count; liver cell carcinoma; major clinical study; male; monocyte; neutrophil; physical examination; prediction; regression analysis; risk factor; sex difference; Student t test; Taiwan; university hospital; adolescent; leukocyte count; middle aged; mortality; neoplasm; proportional hazards model; retrospective study; Taiwan; Adolescent; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Humans; Leukocyte Count; Middle Aged; Mortality; Neoplasms; Proportional Hazards Models; Retrospective Studies; Taiwan |
顯示於: | 醫學系 |
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