https://scholars.lib.ntu.edu.tw/handle/123456789/540132
標題: | Etiology and clinical features of isosexual precocious puberty in Taiwanese girls: Twenty-three years' experience in National Taiwan University Hospital | 作者: | CHENG-TING LEE YI-CHING TUNG WEN-YU TSAI |
關鍵字: | Functional ovarian cyst; Hypothalamic hamartoma; Precocious puberty | 公開日期: | 2009 | 出版社: | Freund Publishing House Ltd | 卷: | 22 | 期: | 10 | 起(迄)頁: | 947-953 | 來源出版物: | Journal of Pediatric Endocrinology and Metabolism | 摘要: | The aim of this study was to elucidate the etiology and clinical features of Taiwanese girls with isosexual precocious puberty. 460 girls with precocious puberty were enrolled in this study. 284 of them had a GnRH test and 179 girls with gonadotropin-dependent precocious puberty (GDPP) underwent brain MRI. Our results showed 7% of these 460 girls had gonadotropin-independent precocious puberty (GIPP). The other 93% patients had GDPP and 96% of them were idiopathic. Functional ovarian cyst and hypothalamic hamartoma were leading causes of GIPP and organic GDPP, respectively. The presence of undetectable basal serum FSH and LH levels had a specificity of 95% in girls with GIPP. Among girls with GDPP, those aged <5 years had a higher percentage of detected CNS lesions than older girls (8% vs 3%). Girls with organic CNS lesions also had more advanced bone age SDS (6.9 ± 3.3 vs 3.3 ± 1.9), larger uterine volume (13.8 ± 12.1 vs 6.6 ± 8.1 cm3), higher basal serum estradiol (33.5 ± 17.1 vs 26.8 ± 18.2 pg/ml), and higher peak LH level after GnRH stimulation (45.2 ± 36.2 vs 25.8 ± 27.3 U/I) than those with idiopathic GDPP. In conclusion, GIPP is uncommon in Taiwanese girls with precocious puberty. Functional ovarian cyst and hypothalamic hamartoma are leading causes of GIPP and organic GDPP, respectively. The presence of neurological deficit, younger age at onset of puberty, presence of menstruation, rapid advance of bone age, markedly enlarged uterus, high serum estradiol, and high peak LH level after GnRH stimulation are suggestive of organic GDPP. ? Freund Publishing House Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71049176599&doi=10.1515%2fJPEM.2009.22.10.947&partnerID=40&md5=6316469d51217ae6baefe01c054e61a5 https://scholars.lib.ntu.edu.tw/handle/123456789/540132 |
ISSN: | 0334-018X | DOI: | 10.1515/JPEM.2009.22.10.947 | SDG/關鍵字: | estradiol; follitropin; gonadorelin; gonadotropin; luteinizing hormone; aged; article; bone age; child; clinical feature; controlled study; estradiol blood level; female; follitropin blood level; hamartoma; human; hypothalamus tumor; luteinizing hormone blood level; major clinical study; menstruation; nervous system injury; neurologic disease; nuclear magnetic resonance imaging; ovary cyst; precocious puberty; preschool child; Taiwan; university hospital; uterus |
顯示於: | 醫學系 |
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