Decrease in Irisin in Patients with Chronic Kidney Disease
Journal
PLoS ONE
Journal Volume
8
Journal Issue
5
Pages
e64025
Date Issued
2013
Author(s)
Abstract
Patients with chronic kidney disease have abnormal energy expenditure and metabolism. The mechanisms underlying altered energy expenditure in uremia are unknown and remain to be elucidated. Irisin is a peroxisome proliferator-activated receptor γ coactivator 1-α-dependent myokine, and it increases energy expenditure in the absence of changes in food intake or activity. We hypothesize that chronic kidney disease patients have altered irisin levels. We measured resting irisin levels in 38 patients with stage 5 chronic kidney disease and in 19 age- and sex-matched normal subjects. Plasma irisin levels were significantly decreased in chronic kidney disease patients (58.59%; 95% CI 47.9%-69.2%, p<0.0001). The decrease in irisin levels was inversely correlated with the levels of blood urea nitrogen and creatinine. Further association analysis revealed that irisin level is independently associated with high-density lipoprotein cholesterol level. Our results suggest that chronic kidney disease patients have lower than normal irisin levels at rest. Furthermore, irisin may play a major role in affecting high-density lipoprotein cholesterol levels and abnormal energy expenditure in chronic kidney disease patients. ? 2013 Wen et al.
SDGs
Other Subjects
C reactive protein; creatinine; glucose; hemoglobin; high density lipoprotein cholesterol; irisin; low density lipoprotein cholesterol; muscle protein; nitrogen; triacylglycerol; unclassified drug; urea; uric acid; adult; article; cholesterol blood level; chronic kidney disease; clinical article; controlled study; creatinine blood level; energy expenditure; enzyme immunoassay; female; hemoglobin blood level; human; human cell; male; patient assessment; protein blood level; protein determination; protein function; urea nitrogen blood level; uremia; Western blotting; Case-Control Studies; Creatinine; Demography; Female; Fibronectins; Humans; Indican; Male; Middle Aged; Muscle Cells; Muscle, Skeletal; Renal Insufficiency, Chronic
Type
journal article