https://scholars.lib.ntu.edu.tw/handle/123456789/540347
標題: | Does Chinese herb nephropathy account for the high incidence of end-stage renal disease in Taiwan? | 作者: | Lin Wu F.-L. YUNG-MING CHEN TAI-SHUAN LAI Shen L.-J. Ho Y.-F. Lee Y.-T. Wu M.-S. SHUEI-LIONG LIN KWAN-DUN WU |
公開日期: | 2012 | 卷: | 120 | 期: | 4 | 起(迄)頁: | c215-c222 | 來源出版物: | Nephron - Clinical Practice | 摘要: | Background: The incidence of end-stage renal disease (ESRD) in Taiwan ranks highest in the world, but the incidence of Chinese herb nephropathy (CHN) is unknown in this country where Chinese herb use is common. Methods: The etiologies of incident ESRD cases from 2000 to 2004 in a single tertiary referral medical center in Taiwan were independently reviewed by two nephrologists through medical records and telephone interview. Patients with obvious causes of ESRD were not diagnosed with CHN, in spite of Chinese herb use. Three categories of CHN (A, B and C) were defined according to the stringency of evidence. Results: Obvious causes of ESRD were identified in 1,359 out of 1,696 newly diagnosed ESRD patients. Among the remainders, 263 had histories of Chinese herb use; 164 patients (mean age 52.7 ± 13.2 years, female 71.6%) had CHN (category A: 51, category B: 38 and category C: 75). Among the three categories, there was no difference in age, gender, body mass index (BMI) or elapsed time from Chinese herb use to the detection of renal failure. In comparison with non-CHN patients (n = 99), more CHN patients were female, had lower BMI, lower blood pressure, shorter duration of Chinese herb use, less severe proteinuria, smaller kidney size, lower levels of hemoglobin and higher serum chloride levels (all p values <0.01). Conclusion: Based on highly stringent diagnostic criteria, nearly 10% of incident ESRD cases were due to CHN. CHN represents a significant cause of ESRD in Taiwan. Copyright ? 2012 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867208318&doi=10.1159%2f000341120&partnerID=40&md5=cc69606fd08f3ca32e30cebf3d93b034 https://scholars.lib.ntu.edu.tw/handle/123456789/540347 |
ISSN: | 1660-2110 | DOI: | 10.1159/000341120 | SDG/關鍵字: | aristolochic acid; chloride; hemoglobin; herbaceous agent; sodium; herbaceous agent; adult; article; blood pressure; body mass; Chinese herb; chinese herb nephropathy; chloride blood level; controlled study; disease duration; disease severity; drug use; female; gynecologic disease; hepatitis; human; incidence; kidney disease; kidney failure; kidney size; major clinical study; male; mortality; nephrologist; priority journal; proteinuria; renal replacement therapy; sex difference; sodium blood level; Taiwan; transitional cell carcinoma; treatment duration; chemically induced; Kidney Failure, Chronic; middle aged; risk factor; Drugs, Chinese Herbal; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Risk Factors; Taiwan |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。