Clinical profiles of multiple myeloma in Asia-An Asian Myeloma Network study
Journal
American Journal of Hematology
Journal Volume
89
Journal Issue
7
Pages
751-756
Date Issued
2014
Author(s)
Kim K.
Lee J.H.
Kim J.S.
Min C.K.
Yoon S.S.
Shimizu K.
Chou T.
Kosugi H.
Suzuki K.
Chen W.
Hou J.
Lu J.
Huang X.-J.
Chng W.J.
Tan D.
Teoh G.
Chim C.S.
Nawarawong W.
Siritanaratkul N.
Durie B.G.
Abstract
The incidence of multiple myeloma (MM) is known to be variable according to ethnicity. However, the differences in clinical characteristics between ethnic groups are not well-defined. In Asian countries, although the incidence of MM has been lower than that of Western countries, there is growing evidence that MM is increasing rapidly. The Asian Myeloma Network decided to initiate the first multinational project to describe the clinical characteristics of MM and the clinical practices in Asia. Data were retrospectively collected from 23 centers in 7 countries and regions. The clinical characteristics at diagnosis, survival rates and initial treatment of 3,405 symptomatic MM patients were described. Median age was 62 years (range, 19-106), with 55.6% of being male. Median overall survival (OS) was 47 months (95% CI 44.0-50.0). Stem cell transplantation was performed in 666 patients who showed better survival rates (79 vs. 41 months, P<0.001). The first-line treatments of 2,970 patients were analyzed. The overall response rate was 71% including very good partial response or better in 31% of the 2,660 patients those were able to be evaluated. New drugs including bortezomib, thalidomide, and lenalidomide were used in 36% of 2,970 patients and affected OS when used as a first-line treatment. Am. J. Hematol. 89:751-756, 2014. ? 2014 Wiley Periodicals, Inc.
SDGs
Other Subjects
beta 2 microglobulin; bortezomib; calcium; creatinine; hemoglobin; immunoglobulin A; immunoglobulin D; immunoglobulin G; immunoglobulin heavy chain; lenalidomide; serum albumin; thalidomide; adult; age distribution; aged; article; Asia; Asian; autologous stem cell transplantation; bone lesion; bone marrow cell; calcium blood level; cancer survival; China; clinical feature; clinical practice; creatinine blood level; diploidy; female; genetic polymorphism; hemoglobin blood level; Hong Kong; human; Japan; Korea; major clinical study; male; multicenter study; multiple myeloma; overall survival; plasma cell; plasmacytoma; priority journal; retrospective study; Singapore; survival rate; Taiwan; Thailand; thrombocyte count; treatment response; very elderly; Adult; Aged; Aged, 80 and over; Asia; Female; Humans; Incidence; Male; Middle Aged; Multiple Myeloma; Prognosis; Retrospective Studies; Survival Analysis; Young Adult
Publisher
Wiley-Liss Inc.
Type
journal article