https://scholars.lib.ntu.edu.tw/handle/123456789/540560
標題: | Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells | 作者: | Chen, Yu-Chen Chuang, Tzu-Yi Liu, Chen-Wei Liu, Chi-Wei Lee, Tzu-Lin Lai, Tsai-Chun YUH-LIEN CHEN |
關鍵字: | EMT; ETS-1; Fibronectin; Particulate matters (PMs); Pulmonary fibrosis | 公開日期: | 2020 | 出版社: | BMC | 卷: | 17 | 期: | 1 | 來源出版物: | Particle and fibre toxicology | 摘要: | Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of proinflammatory intracellular adhesion molecule-1 (ICAM-1) through the IL-6/AKT/STAT3/NF-κB pathway in A549 cells. However, the role of O-PMs in epithelial-mesenchymal transition (EMT) development and pulmonary fibrosis and the related mechanisms have not been determined. The aim of this study was to investigate the effects of O-PMs on the pathogenesis of EMT and pulmonary fibrosis as well as the expression of ETS-1 and NF-κB p65, in vitro and in vivo. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/540560 | ISSN: | 1743-8977 | DOI: | 10.1186/s12989-020-00373-z | SDG/關鍵字: | fibronectin; n acetylprolylhistidylserylcysteinylasparagine amide; transcription factor Ets 1; transcription factor RelA; uvomorulin; vimentin; fibronectin; immunoglobulin enhancer binding protein; transcription factor RelA; A-549 cell line; animal experiment; animal model; animal tissue; Article; cell migration; controlled study; epithelial mesenchymal transition; epithelium cell; human; human cell; human tissue; in vitro study; in vivo study; lung fibrosis; lung parenchyma; male; mouse; nonhuman; particulate matter; pathogenesis; priority journal; protein expression; signal transduction; air pollutant; animal; epithelial mesenchymal transition; lung; lung alveolus epithelium cell; lung fibrosis; metabolism; particulate matter; pathophysiology; toxicity; A549 Cells; Air Pollutants; Alveolar Epithelial Cells; Animals; Epithelial-Mesenchymal Transition; Fibronectins; Humans; Lung; Mice; NF-kappa B; Particulate Matter; Pulmonary Fibrosis; Transcription Factor RelA |
顯示於: | 解剖學暨細胞生物學科所 |
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