https://scholars.lib.ntu.edu.tw/handle/123456789/540616
Title: | Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen | Authors: | CHYI-FENG JAN Liu T.-H. Ho C.-H. Chien Y.-C. CHE-JUI CHANG FEI-RAN GUO KUO-CHIN HUANG |
Issue Date: | 2020 | Publisher: | Oxford University Press | Journal Volume: | 37 | Journal Issue: | 1 | Start page/Pages: | 30-35 | Source: | Family Practice | Abstract: | Objectives: To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs). Methods: We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination. Results: The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml. Conclusion: A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college. ? 2019 The Author(s) 2019. Published by Oxford University Press. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080844412&doi=10.1093%2ffampra%2fcmz039&partnerID=40&md5=c0249cc6cf7b510b35140de81ec3541e https://scholars.lib.ntu.edu.tw/handle/123456789/540616 |
ISSN: | 0263-2136 | DOI: | 10.1093/fampra/cmz039 | SDG/Keyword: | hepatitis B antibody; hepatitis B surface antigen; recombinant hepatitis B vaccine; hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine; adult; antibody titer; Article; cohort analysis; college student; controlled study; dose response; female; graduate student; health center; hepatitis B; Hepatitis B virus; human; male; retrospective study; revaccination; Taiwan; university hospital; adolescent; hepatitis B; immunology; procedures; secondary immunization; young adult; Adolescent; Adult; Cohort Studies; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization, Secondary; Male; Retrospective Studies; Taiwan; Young Adult [SDGs]SDG3 |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.