https://scholars.lib.ntu.edu.tw/handle/123456789/540619
標題: | Metabolic Characteristics of a Novel Ultrasound Quantitative Diagnostic Index for Nonalcoholic Fatty Liver Disease | 作者: | Liao Y.-Y. Yeh C.-K. KUO-CHIN HUANG Tsui P.-H. KUEN-CHEH YANG |
公開日期: | 2019 | 出版社: | Nature Research | 卷: | 9 | 期: | 1 | 起(迄)頁: | 7922 | 來源出版物: | Scientific Reports | 摘要: | Nonalcoholic fatty liver disease (NAFLD) is an emerging epidemic worldwide and is regarded as a hepatic manifestation of metabolic syndrome (MetS). Only a few studies have discussed the biological features associated with quantitative assessment of ultrasound for characterizing NAFLD. Our aim was to delineate relevant metabolic characteristics using a new quantitative tool, the ultrasound quantitative diagnostic index (QDI). A total of 394 ultrasound data were analyzed to extract texture-feature parameters, the signal-to-noise ratio (SNR), and the slope of the center frequency downshift (CFDS) for determining the QDI. The texture index, SNR, and CFDS slope were all negatively correlated with high-density lipoprotein and positively correlated with other anthropometric indices and metabolic factors (all P < 0.05). The SNR had the greatest contribution to anthropometric and biochemical factors, followed by the texture index and CFDS slope. An increase in 1 unit of QDI score engendered a 9% higher risk of MetS, reflecting that the tool is feasible for use in identifying MetS (area under the receiver operating characteristic curve: 0.89). The QDI was correlated with metabolic factors and an independent predictor for MetS. Thus, this QDI might be a feasible method for use in clinical surveillance, epidemiology research, and metabolic function evaluations in patients with NAFLD. ? 2019, The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067295875&doi=10.1038%2fs41598-019-44453-3&partnerID=40&md5=6c03080f8316f1a4f81c98b4d49c8838 https://scholars.lib.ntu.edu.tw/handle/123456789/540619 |
ISSN: | 2045-2322 | DOI: | 10.1038/s41598-019-44453-3 | SDG/關鍵字: | adult; diagnostic imaging; echography; female; human; liver; male; metabolic syndrome X; nonalcoholic fatty liver; signal noise ratio; Adult; Female; Humans; Liver; Male; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Signal-To-Noise Ratio; Ultrasonography |
顯示於: | 醫學系 |
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