|Title:||General and abdominal adiposity and risk of death in HBV versus non-HBV carriers: A 10-year population-based cohort study||Authors:||Lin W.-Y.
|Issue Date:||2016||Publisher:||Lippincott Williams and Wilkins||Journal Volume:||95||Journal Issue:||2||Start page/Pages:||e2162||Source:||Medicine (United States)||Abstract:||
Both obesity and hepatitis B virus (HBV) infection increase the risk of death. We investigate the association between general and central obesity and all-cause mortality among adult Taiwanese HBV versus non-HBV carriers. A total of 19,850 HBV carriers and non-hepatitis C virus (HCV) carriers, aged 20 years and older at enrollment in 1998 to 1999 in Taiwan, were matched to 79,400 non-HBV and non-HCV carriers (1:4). Cox proportional-hazards models were used to estimate the relative risks for all-cause mortality during a maximum follow-up period of 10 years. Four obesity-related anthropometric indices - body mass index (BMI), waist circumference, waist-to-hip ratio, and waist-to-height ratio - were the main variables of interest. During the follow-up period, 628 and 2366 participants died among HBV and non-HBV carriers, respectively. Both underweight and general obesity were associated with an increased risk of death. The highest risk of all-cause death in relation to BMI was found in the HBV carriers with underweight (BMI <18.5 kg/m2) and non-HBV carriers with obesity (BMI ?30 kg/m2). The lowest risks of all-cause death in relation to abdominal adiposity were found at the third quartiles of waist circumference, waist-to-hip ratio, and waist-to-height ratio among HBV carriers, but in the second quartiles among non-HBV carriers. For those with pre-existing liver disease among HBV carriers, patients with underweight have higher risk of death than those with obesity. Hepatitis B virus carriers with underweight have higher risk of death than non-HBV carriers. HBV carriers with mild abdominal obesity have the lowest risk of death, but not in the non-HBV carriers. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved.
|ISSN:||0025-7974||DOI:||10.1097/MD.0000000000002162||SDG/Keyword:||abdominal obesity; adult; Article; body mass; cause of death; cohort analysis; female; general obesity; Hepatitis B virus; human; major clinical study; male; mortality; obesity; population research; priority journal; prospective study; risk of death; Taiwan; underweight; virus carrier; waist circumference; waist hip ratio; waist to height ratio; abdominal fat; case control study; chronic hepatitis B; complication; epidemiology; mortality; obesity; abdominal obesity; anthropometry; disease association; disease severity; follow up; hepatitis B; heterozygote; liver function; risk factor; thrombocyte count; Abdominal Fat; Adiposity; Adult; Body Mass Index; Case-Control Studies; Female; Hepatitis B, Chronic; Humans; Male; Obesity; Prospective Studies; Taiwan; Waist Circumference; Waist-Height Ratio; alanine aminotransferase; albumin; aspartate aminotransferase; hepatitis B surface antigen; hepatitis C antibody
|Appears in Collections:||醫學系|
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