https://scholars.lib.ntu.edu.tw/handle/123456789/540670
標題: | Subclinical hypothyroidism is associated with increased risk for cancer mortality in adult taiwanese-A 10 years population- Based cohort | 作者: | FEN-YU TSENG Lin W.-Y. Li C.-I. Li T.-C. Lin C.-.C. KUO-CHIN HUANG |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 4 | 起(迄)頁: | e0122955 | 來源出版物: | PLoS ONE | 摘要: | Background The association between subclinical hypothyroidism (SCH) and cancer mortality is seldom discussed. Methods A total of 115,746 participants without thyroid disease history, aged 20 and above, were recruited from four nationwide health screening centers in Taiwan from 1998 to 1999. SCH was defined as a serum thyroid-stimulating hormone (TSH) level of 5.0-19.96 mIU/L with normal total thyroxine concentrations. Euthyroidism was defined as a serum TSH level of 0.47-4.9 mIU/L. Cox proportional hazards regression analyses were used to estimate the relative risks (RRs) of death from cancer for adults with SCH during a 10-year follow-up period. Results Among 115,746 adults, 1,841 had SCH (1.6%) and 113,905 (98.4%) had euthyroidism. There were 1,532 cancer deaths during the 1,034,082 person-years follow-up period. Adjusted for age, gender, body mass index, diabetes, hypertension, dyslipidemia, smoking, alcohol drinking, betel nut chewing, physical activity, income, and education level, the RRs (95% confidence interval) of cancer deaths among subjects with SCH versus euthyroid subjects were 1.51 (1.06 to 2.15). Cancer site analysis revealed a significant increased risk of bone, skin and breast cancer among SCH subjects (RR 2.79, (1.01, 7.70)). The risks of total cancer deaths were more prominent in the aged (RR 1.71, (1.02 to 2.87)), in females (RR 1.69 (1.08 to 2.65)), and in heavy smokers (RR 2.24, (1.19 to 4.21)). Conclusions Subjects with SCH had a significantly increased risk for cancer mortality among adult Taiwanese. This is the first report to demonstrate the association between SCH and cancer mortality. ? 2015 Tseng et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926657508&doi=10.1371%2fjournal.pone.0122955&partnerID=40&md5=4af11bb3e3af01d21660f4ebef53fee2 https://scholars.lib.ntu.edu.tw/handle/123456789/540670 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0122955 | SDG/關鍵字: | thyrotropin; thyroxine; adult; age distribution; alcohol consumption; Article; betel nut; body mass; bone cancer; breast cancer; cancer mortality; cancer risk; diabetes mellitus; dyslipidemia; educational status; female; gender; human; hypertension; hypothyroidism; major clinical study; male; physical activity; population research; risk assessment; skin cancer; smoking; Taiwanese; thyrotropin blood level; asymptomatic disease; cohort analysis; complication; epidemiology; hypothyroidism; Kaplan Meier method; middle aged; mortality; Neoplasms; proportional hazards model; risk factor; Taiwan; Piper betel; Adult; Asymptomatic Diseases; Cohort Studies; Female; Humans; Hypothyroidism; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasms; Proportional Hazards Models; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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