https://scholars.lib.ntu.edu.tw/handle/123456789/540691
標題: | Iron deficiency is associated with increased risk for cardiovascular disease and all-cause mortality in the elderly living in long-term care facilities | 作者: | Hsu H.-S. Li C.-I. Liu C.-S. Lin C.-C. KUO-CHIN HUANG Li T.-C. Huang H.-Y. Lin W.-Y. |
關鍵字: | Cardiovascular disease; Elderly; Institutionalization; Iron deficiency; Mortality | 公開日期: | 2013 | 卷: | 29 | 期: | 5 | 起(迄)頁: | 737-743 | 來源出版物: | Nutrition | 摘要: | Objective: The association between serum iron status, cardiovascular disease (CVD), and all-cause mortality remains controversial in the elderly. In the present study, we aim to determine the relevance of serum iron level on the incidences of CVD and all-cause mortality in an elderly population. Methods: A baseline cohort of 336 participants, aged ?65 y, was recruited from eight long-term care facilities between 2002 and 2003. The degree of iron deficiency was defined based on the serum iron level (mild: 40 mg/dL ?serum iron <60 mg/dL; severe: serum iron <40 mg/dL). Cox proportional hazard regression analyses were adopted to evaluate the relative risks (RRs) of CVD and all-cause death. Taiwan's Department of Health provided the mortality data. Results: There were 210 deaths during a 5-y follow-up period, 62 of which were due to CVD. The prevalence of iron deficiency among the subjects was 50.3%. Age, sex, body mass index, waist circumference, mean arterial pressure, performance status, lifestyle factors, blood glucose, hemoglobin, lipid, albumin, and high sensitivity C-reactive protein levels were adjusted to compare the RRs of the subjects. The RRs (95% confidence interval) of CVD and all-cause mortality among mildly iron-deficient subjects were 1.08 (0.51-2.29) and 1.63 (1.14-2.31), respectively, and 2.77 (1.28-5.99) and 1.96 (1.26-3.04), respectively, among severely iron-deficient subjects. The severity of iron deficiency was positively associated with CVD and all-cause mortality. Conclusions: These results suggest that iron deficiency is independently associated with CVD and all-cause mortality in elderly Taiwanese living in long-term care facilities. ? 2013 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876312844&doi=10.1016%2fj.nut.2012.10.015&partnerID=40&md5=07765912b6a9d18dcb28a4cef8a42ca3 https://scholars.lib.ntu.edu.tw/handle/123456789/540691 |
ISSN: | 0899-9007 | DOI: | 10.1016/j.nut.2012.10.015 | SDG/關鍵字: | albumin; C reactive protein; glucose; hemoglobin; iron; lipid; aged; albumin blood level; article; bleeding; body mass; cardiovascular disease; cardiovascular mortality; cardiovascular risk; cause of death; chronic inflammation; cohort analysis; disease association; disease severity; female; follow up; glucose blood level; health care facility; hemoglobin blood level; human; incidence; infection; iron blood level; iron deficiency; long term care; longitudinal study; major clinical study; male; malnutrition; mean arterial pressure; observational study; prevalence; priority journal; survival rate; Taiwan; waist circumference; Aged; Aged, 80 and over; Anemia, Iron-Deficiency; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confidence Intervals; Female; Humans; Iron; Male; Prevalence; Risk Factors; Severity of Illness Index; Taiwan |
顯示於: | 醫學系 |
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