Insulin resistance, obesity, and metabolic syndrome among non-diabetic pre- and post-menopausal women in North Taiwan
Journal
International Journal of Obesity
Journal Volume
30
Journal Issue
6
Pages
912-917
Date Issued
2006
Author(s)
Abstract
Objective: To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan. Design: A cross-sectional study in a medical center in North Taiwan. Subjects: Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9±5.4 years) were recruited. Measurements: The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm). Results: The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome. Conclusion: The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan. ? 2006 Nature Publishing Group All rights reserved.
SDGs
Other Subjects
glucose; high density lipoprotein cholesterol; insulin; lipid; adult; anthropometry; article; controlled study; diabetes mellitus; female; glucose blood level; homeostasis; human; hyperglycemia; insulin blood level; insulin resistance; lipid blood level; major clinical study; menopause; metabolic syndrome X; multivariate logistic regression analysis; obesity; postmenopause; prevalence; priority journal; Taiwan; waist circumference; Adult; Anthropometry; Asian Continental Ancestry Group; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Insulin; Insulin Resistance; Lipids; Metabolic Syndrome X; Middle Aged; Obesity; Postmenopause; Premenopause; Prevalence; Taiwan
Type
journal article