https://scholars.lib.ntu.edu.tw/handle/123456789/540759
標題: | Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water | 作者: | KUO-CHIN HUANG Yang C.-C. Lee K.-T. Chien C.-T. |
關鍵字: | Electrolyzed reduced water; End-stage renal diseases; Hemodialysis; Reactive oxygen species | 公開日期: | 2003 | 出版社: | Blackwell Publishing Inc. | 卷: | 64 | 期: | 2 | 起(迄)頁: | 704-714 | 來源出版物: | Kidney International | 摘要: | Background. Increased oxidative stress in end-stage renal disease (ESRD) patients may oxidize macromolecules and consequently lead to cardiovascular events during chronic hemodialysis. Electrolyzed reduced water (ERW) with reactive oxygen species (ROS) scavenging ability may have a potential effect on reduction of hemodialysis-induced oxidative stress in ESRD patients. Methods. We developed a chemiluminescence emission spectrum and high-performance liquid chromatography analysis to assess the effect of ERW replacement on plasma ROS (H2O2 and HOCl) scavenging activity and oxidized lipid or protein production in ESRD patients undergoing hemodialysis. Oxidized markers, dityrosine, methylguanidine, and phosphatidylcholine hydroperoxide, and inflammatory markers, interleukin 6 (IL-6), and C-reactive protein (CRP) were determined. Results. Although hemodialysis efficiently removes dityrosine and creatinine, hemodialysis increased oxidative stress, including phosphatidylcholine hydroperoxide, and methylguanidine. Hemodialysis reduced the plasma ROS scavenging activity, as shown by the augmented reference H2O2 and HOCl counts (RH2O2 and RHOCl, respectively) and decreased antioxidative activity (expressed as total antioxidant status in this study). ERW administration diminished hemodialyis-enhanced RH2O2 and RHOCl, minimized oxidized and inflammatory markers (CRP and IL-6), and partly restored total antioxidant status during 1-month treatment. Conclusion. This study demonstrates that hemodialysis with ERW administration may efficiently increase the H2O2- and HOCl-dependent antioxidant defense and reduce H2O2- and HOCl-induced oxidative stress. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0038119368&doi=10.1046%2fj.1523-1755.2003.00118.x&partnerID=40&md5=f8ca02ec2475804576644b49cad5bc45 https://scholars.lib.ntu.edu.tw/handle/123456789/540759 |
ISSN: | 0085-2538 | DOI: | 10.1046/j.1523-1755.2003.00118.x | SDG/關鍵字: | C reactive protein; dityrosine; hydrogen peroxide; hypochlorite; interleukin 6; methylguanidine; tyrosine derivative; unclassified drug; water; adult; aged; antioxidant activity; article; chemoluminescence; clinical article; controlled study; female; hemodialysis; high performance liquid chromatography; human; kidney failure; male; oxidative stress; priority journal |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。