https://scholars.lib.ntu.edu.tw/handle/123456789/540892
標題: | Clinicopathological features and outcome of esophageal neuroendocrine tumor: A retrospective multicenter survey by the digestive endoscopy society of Taiwan | 作者: | Wu I.-C. Chu Y.-Y. Wang Y.-K. Tsai C.-L. Lin J.-C. Kuo C.-H. Shih H.-Y. Chung C.-S. Hu M.-L. Sun W.-C. Wang J.P. HSIU-PO WANG |
關鍵字: | Endoscopy; Esophagus; Multicenter study; Neuroendocrine tumor | 公開日期: | 2021 | 出版社: | Elsevier B.V. | 卷: | 120 | 期: | 1 | 起(迄)頁: | 508-514 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background & aims: Esophageal neuroendocrine tumors (NET) are very rare and mostly carcinomic, carrying poor prognosis. There is still no guideline or consensus on the treatment for esophageal NET. Methods: Patients with histologically-proven esophageal neuroendocrine tumor were recruited from 9 hospitals in Taiwan between 2002 and 2017. Clinical, laboratory, radiological, endoscopic, pathological data, treatment strategies, follow-up periods, and survivals were collected retrospectively. Results: In total, 39 esophageal NET were analyzed and 38 were neuroendocrine carcinoma (NEC). Sixteen (41%) patients had mixed components with either adenocarcinoma (N = 9, 23%) or squamous-cell carcinoma (SCC) (N = 7, 18%). 64.1% of the patients experienced dysphagia and ulcerative mass was the most comment endoscopic finding. There was a higher proportion of drinkers (54.1%), betel chewers (21.6%) and smokers (64.9%) among the patients than in the general population in Taiwan. Five patients (12.8%) had been diagnosed with other cancers. Definite chemoradiotherapy (N = 14, 35.9%) and surgery (N = 7, 17.9%) were the major treatment. Patients with Ki-67% above the median level (50%) in the tumors tended to have worse survival (P = 0.06). However, presence of mixed component was not a significant survival predictor in our study (P = 0.56). Conclusion: Mixed component of an esophageal NET is commonly observed. Staged workup and the principle of treatment can follow that for the common cancer type of esophagus. The risk factors and behaviors of esophageal NEC in Taiwan seem to be similar to that of esophageal SCC. ? 2020 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087033455&doi=10.1016%2fj.jfma.2020.06.024&partnerID=40&md5=5fc7c604208729dd01a878a0f35ca801 https://scholars.lib.ntu.edu.tw/handle/123456789/540892 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2020.06.024 | SDG/關鍵字: | antineoplastic agent; CD56 antigen; chromogranin; chromogranin A; Ki 67 antigen; synaptophysin; adult; aged; Article; betel quid; cancer adjuvant therapy; cancer surgery; chemoradiotherapy; clinical article; clinical feature; drinking behavior; dysphagia; endoscopic submucosal dissection; esophageal adenocarcinoma; esophageal squamous cell carcinoma; esophagus biopsy; esophagus tumor; female; follow up; gastroesophageal junction; health survey; histopathology; human; human tissue; immunohistochemistry; male; middle aged; multicenter study; neoadjuvant therapy; neuroendocrine carcinoma; neuroendocrine tumor; retrospective study; small cell carcinoma; smoking; tumor volume; esophagus tumor; gastrointestinal endoscopy; neuroendocrine tumor; prognosis; Taiwan; Endoscopy, Gastrointestinal; Esophageal Neoplasms; Humans; Neuroendocrine Tumors; Prognosis; Retrospective Studies; Taiwan |
顯示於: | 醫學系 |
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