https://scholars.lib.ntu.edu.tw/handle/123456789/540968
標題: | Associations of circulating gut hormone and adipocytokine levels with the spectrum of gastroesophageal reflux disease | 作者: | PING-HUEI TSENG WEI-SHIUNG YANG JYH-MING LIOU YI-CHIA LEE HSIU-PO WANG Lin J.-T. MING-SHIANG WU |
公開日期: | 2015 | 出版社: | Public Library of Science | 卷: | 10 | 期: | 10 | 來源出版物: | PLoS ONE | 摘要: | Objective The pathogenesis of gastroesophageal reflux disease (GERD) is complex and poorly understood. We aim to investigate the association of various circulating peptide hormones with heterogenous manifestations of GERD. Methods One hundred and four patients that had experienced typical GERD symptoms (heartburn and/or acid regurgitation) for at least 3 episodes per week in the past 3 months were enrolled. All patients received a baseline assessment of symptom severity and frequency with the Reflux Disease Questionnaire and an upper endoscopy to classify GERD into erosive esophagitis (EE, n = 67), non-erosive esophagitis (NE, n = 37), and Barrett's esophagus (BE, n = 8). Fifty asymptomatic subjects with an endoscopically normal esophagus were recruited as the control group. Complete anthropometric measures and blood biochemistry were obtained and fasting serum levels of adipocytokines (adiponectin and leptin) and gut hormones (ghrelin and peptide YY (PYY)) were determined by enzyme-linked immunosorbent assay in all subjects. Results All circulating peptide hormone levels were not statistically different between the GERD and control groups. However, GERD patients appeared to have lower PYY levels [median (25th-75th percentile), 80.1 (49.8-108.3) vs. 99.4 (65.8-131.9) pg/ml, p = 0.057] compared with control subjects. Among the GERD patients, ghrelin levels were inversely associated with the frequency and severity of acid regurgitation. In male GERD patients, EE was associated with significantly higher PYY levels [107.0 (55.0-120.8) vs. 32.8 (28.7-84.5) pg/ml, p = 0.026] but lower adiponectin levels [6.7 (5.6-9.3) vs. 9.9 (9.6-10.6) μg/ml, p = 0.034] than NE. Patients with BE had significantly lower adiponectin levels [6.0 (5.1-9.2) vs. 9.2 (7.1-11.2) μg/ml, p = 0.026] than those without BE. Conclusions Humoral derangement of circulating peptide hormones might participate in inflammation and symptom perception in patients suffering from GERD. Further studies to clarify the exact role of these hormones in the pathogenesis of GERD are warranted. ? 2015 Tseng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949548681&doi=10.1371%2fjournal.pone.0141410&partnerID=40&md5=359d488f3934ed7eaede3ec15053e720 https://scholars.lib.ntu.edu.tw/handle/123456789/540968 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0141410 | SDG/關鍵字: | adipocytokine; adiponectin; gastrointestinal hormone; ghrelin; leptin; peptide hormone; peptide YY; adiponectin; ghrelin; leptin; peptide YY; adult; anthropometry; Article; asymptomatic disease; Barrett esophagus; blood biochemistry; controlled study; disease classification; disease severity; endoscopy; enzyme linked immunosorbent assay; female; gastroesophageal reflux; heartburn; hormone blood level; human; major clinical study; male; morbidity; questionnaire; Reflux Disease Questionnaire; reflux esophagitis; Barrett esophagus; blood; gastroesophageal reflux; genetics; middle aged; pathology; Adiponectin; Adult; Barrett Esophagus; Female; Gastroesophageal Reflux; Ghrelin; Heartburn; Humans; Leptin; Male; Middle Aged; Peptide YY; Surveys and Questionnaires |
顯示於: | 醫學系 |
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