https://scholars.lib.ntu.edu.tw/handle/123456789/540975
標題: | Blood glucose concentration and risk of pancreatic cancer: Systematic review and dose-response meta-analysis | 作者: | WEI-CHIH LIAO YU-KANG TU MING-SHIANG WU Lin J.-T. HSIU-PO WANG KUO-LIONG CHIEN |
公開日期: | 2015 | 出版社: | BMJ Publishing Group | 卷: | 349 | 來源出版物: | BMJ (Online) | 摘要: | Objective: To evaluate potential linear and non-linear dose-response relations between blood glucose and risk of pancreatic cancer. Design: Systematic review and dose-response meta-analysis of prospective observational studies. Data sources: Search of PubMed, Scopus, and related reviews before 30 November 2013 without language restriction. Eligibility criteria: Prospective studies evaluating the association between blood glucose concentration and pancreatic cancer. Retrospective and cross sectional studies excluded to avoid reverse causality. Data extraction and synthesis: Two reviewers independently extracted relevant information and assessed study quality with the Newcastle-Ottawa scale. Random effects dose-response meta-analysis was conducted to assess potential linear and non-linear dose-response relations. Results: Nine studies were included for analysis, with a total of 2408 patients with pancreatic cancer. There was a strong linear dose-response association between fasting blood glucose concentration and the rate of pancreatic cancer across the range of prediabetes and diabetes. No non-linear association was detected. The pooled rate ratio of pancreatic cancer per 0.56 mmol/L (10 mg/dL) increase in fasting blood glucose was 1.14 (95% confidence interval 1.06 to 1.22; P<0.001) without significant heterogeneity. Sensitivity analysis excluding blood glucose categories in the range of diabetes showed similar results (pooled rate ratio per 0.56 mmol/L increase in fasting blood glucose was 1.15, 95% confidence interval 1.05 to 1.27; P=0.003), strengthening the association between prediabetes and pancreatic cancer. Conclusions: Every 0.56 mmol/L increase in fasting blood glucose is associated with a 14% increase in the rate of pancreatic cancer. As prediabetes can be improved or even reversed through lifestyle changes, early detection of prediabetes coupled with lifestyle changes could represent a viable strategy to curb the increasing incidence of pancreatic cancer. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930220817&doi=10.1136%2fbmj.g7371&partnerID=40&md5=fd6248d904dca37e98020bd25273cde7 https://scholars.lib.ntu.edu.tw/handle/123456789/540975 |
ISSN: | 0959-8146 | DOI: | 10.1136/bmj.g7371 | SDG/關鍵字: | glucose; hemoglobin A1c; glucose blood level; Article; cancer mortality; cancer prevention; cancer risk; diabetes mellitus; disease association; dose response; glucose blood level; human; impaired glucose tolerance; incidence; lifestyle modification; observational study; pancreas cancer; priority journal; prospective study; risk factor; sex difference; systematic review; analysis; biometry; blood; complication; early diagnosis; glucose blood level; health behavior; hyperglycemia; meta analysis; Pancreatic Neoplasms; Prediabetic State; psychology; statistics; Biometry; Blood Glucose; Early Diagnosis; Health Behavior; Humans; Hyperglycemia; Observational Studies as Topic; Pancreatic Neoplasms; Prediabetic State; Risk Factors; Statistics as Topic |
顯示於: | 醫學系 |
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