https://scholars.lib.ntu.edu.tw/handle/123456789/541025
標題: | Can clinical features stratify use of endoscopy for dyspeptic patients with high background prevalence of upper gastrointestinal cancer? | 作者: | Hsu Y.-C. Yang T.-H. JYH-MING LIOU Hsu W.-L. Lin H.-J. Wu H.-T. Lin J.-T. HSIU-PO WANG MING-SHIANG WU |
公開日期: | 2012 | 卷: | 44 | 期: | 3 | 起(迄)頁: | 218-223 | 來源出版物: | Digestive and Liver Disease | 摘要: | Background: Whether clinical features can stratify priority of endoscopy remains controversial for dyspeptic patients with high background prevalence of upper gastrointestinal cancer. Aim: To examine the predictive performance of clinical features for cancerous lesions in dyspeptic patients in Taiwan. Methods: Between April 2008 and July 2009, 2530 consecutive dyspeptic outpatients underwent prospective evaluation with standardized questionnaire and then upper gastrointestinal endoscopy. Performance of using age thresholds and alarm symptoms to predict malignancy was determined. Independent risk factors associated with malignancy and those with negative endoscopic findings were identified. Results: Malignant lesions were found in 31 patients (1.2%) and were independently associated with age, male gender, gastrointestinal bleeding, weight loss, and alcohol consumption. Any symptom of weight loss, bleeding and dysphagia, or simply age >45 years predicted 97% of cancer cases, with the sensitivity, specificity, positive and negative predictive values being 96.8%, 29.3%, 1.7%, and 99.9%, respectively. This strategy achieved a low negative likelihood ratio (0.11) and a high diagnostic odds ratio (12.45). Negative endoscopic finding (n=1377, 54.4%) was independently associated with younger age, female gender, no use of non-steroidal anti-inflammatory drug, and no tobacco or alcohol consumption. Conclusions: Absence of weight loss, dysphagia, and gastrointestinal bleeding predicts low likelihood of malignancy in dyspeptic Taiwanese patients aged <45 years. ? 2011 Editrice Gastroenterologica Italiana S.r.l. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856576228&doi=10.1016%2fj.dld.2011.10.012&partnerID=40&md5=bafb3e3622be68117e9a5ecda95dde5a https://scholars.lib.ntu.edu.tw/handle/123456789/541025 |
ISSN: | 1590-8658 | DOI: | 10.1016/j.dld.2011.10.012 | SDG/關鍵字: | adult; age; alcohol consumption; article; cancer diagnosis; cancer risk; clinical feature; digestive system cancer; disease association; dyspepsia; dysphagia; endoscopy; female; gastrointestinal hemorrhage; gender; human; major clinical study; male; predictive value; prevalence; priority journal; questionnaire; risk assessment; sensitivity and specificity; Taiwan; upper gastrointestinal tract; weight reduction; Age Factors; Alcohol Drinking; Deglutition Disorders; Dyspepsia; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hemorrhage; Gastrointestinal Neoplasms; Humans; Logistic Models; Male; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prospective Studies; Questionnaires; Sex Factors; Taiwan; Weight Loss |
顯示於: | 醫學系 |
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