https://scholars.lib.ntu.edu.tw/handle/123456789/541041
標題: | Performance of narrow band imaging and magnification endoscopy in the prediction of therapeutic response in patients with gastroesophageal reflux disease | 作者: | PING-HUEI TSENG CHIEN-CHUAN CHEN HAN-MO CHIU WEI-CHIH LIAO MING-SHIANG WU Lin J.-T. YI-CHIA LEE HSIU-PO WANG |
公開日期: | 2011 | 卷: | 45 | 期: | 6 | 起(迄)頁: | 501-506 | 來源出版物: | Journal of Clinical Gastroenterology | 摘要: | BACKGROUND: Imaging-enhanced endoscopy enhances the contrast of the mucosal surface and helps in the diagnosis of gastroesophageal reflux disease. However, whether the increased detection of subtle erosive foci corresponds to the effect of acid suppression remains elusive. GOALS: We aim to evaluate the utility of narrow band imaging with and without magnification endoscopy in the prediction of therapeutic response in patients with reflux. STUDY: Endoscopic evaluation with conventional white light, narrow band imaging, and narrow band imaging with magnification was performed sequentially in consecutive patients with reflux. All patients received proton pump inhibitor for 14 days. Their therapeutic responses were correlated with the baseline endoscopic findings, including mucosal breaks under standard endoscopy, mucosal brownish changes under narrow band imaging, and increased and/or dilated intrapapillary capillary loops or microerosions under narrow band imaging with magnification. RESULTS: Of a total of 82 patients, 22 (26.8%) patients were diagnosed with erosive disease under standard endoscopy. Among the remaining 60 (73.2%) patients, 14 (23.3%) and 30 (50%) were considered erosive under narrow band imaging and narrow band imaging with magnification, respectively. Sixty-five (79.3%) patients showed a positive therapeutic response. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in predicting therapeutic response were 33.8%, 100%, 100%, 28.3%, and 47.6%, respectively, for standard endoscopy; 52.3%, 88.2%, 94.4%, 32.6%, and 59.8%, respectively, for narrow band imaging; and 70.8%, 64.7%, 88.4%, 36.6%, and 69.5%, respectively, for narrow band imaging with magnification. CONCLUSIONS: Narrow band imaging with and without magnification endoscopy substantially improve our ability to predict therapeutic response in patients with gastroesophageal reflux. ? 2011 Lippincott Williams & Wilkins, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958795392&doi=10.1097%2fMCG.0b013e3181eeb115&partnerID=40&md5=d103a1a826654be47e5f90bf8078ca8d https://scholars.lib.ntu.edu.tw/handle/123456789/541041 |
ISSN: | 0192-0790 | DOI: | 10.1097/MCG.0b013e3181eeb115 | SDG/關鍵字: | rabeprazole; accuracy; adult; article; diagnostic test accuracy study; female; gastroesophageal reflux; human; magnifying endoscopy; major clinical study; male; narrow band imaging; prediction; predictive value; priority journal; sensitivity and specificity; treatment response; Adult; Diagnostic Imaging; Endoscopy, Digestive System; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Mucous Membrane; Predictive Value of Tests; Proton Pump Inhibitors; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。