https://scholars.lib.ntu.edu.tw/handle/123456789/541125
Title: | The serial changes of ghrelin and leptin levels and their relations to weight loss after laparoscopic minigastric bypass surgery | Authors: | JYH-MING LIOU Lin J.-T. Lee W.-J. HSIU-PO WANG YI-CHIA LEE HAN-MO CHIU MING-SHIANG WU |
Issue Date: | 2008 | Journal Volume: | 18 | Journal Issue: | 1 | Start page/Pages: | 84-89 | Source: | Obesity Surgery | Abstract: | Background: The ghrelin and leptin levels have been reported to be correlated with weight loss after bariatric surgery. However, the serial changes of ghrelin and leptin levels after laparoscopic minigastric bypass surgery (LMGBP) have not been reported yet. Therefore, we aimed to evaluate their serial changes and to analyze their relations to weight reduction after LMGBP. Methods: Serial fasting serum leptin and ghrelin concentrations were measured in 68 morbidly obese patients before (M0) and 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months after LMGBP surgery. The correlations between ghrelin, insulin, and leptin concentrations and weight reduction were analyzed. Results: Leptin levels were significantly reduced at 1, 3, 6, and 12 months after surgery, respectively (vs M0, p?0.001), whereas the ghrelin concentrations were not significantly changed after surgery. The percent of excess BMI lost (%EBL) 12 months after surgery was negatively correlated with higher preoperative ghrelin concentrations (p?=?0.004) and larger preoperative BMI (p?=?0.002) in the multivariate analysis. Conclusion: Higher preoperative ghrelin concentrations and larger BMI are predictive of less %EBL at 12 months after LMGBP surgery. ? 2007 Springer Science + Business Media B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-45549092609&doi=10.1007%2fs11695-007-9305-x&partnerID=40&md5=e62e31833cc4a3027d60a07997651adb https://scholars.lib.ntu.edu.tw/handle/123456789/541125 |
ISSN: | 0960-8923 | DOI: | 10.1007/s11695-007-9305-x | SDG/Keyword: | ghrelin; leptin; ghrelin; insulin; leptin; adult; article; body mass; clinical evaluation; controlled study; female; human; laparoscopic surgery; major clinical study; male; morbid obesity; multivariate analysis; preoperative period; priority journal; statistical significance; stomach bypass; treatment duration; weight reduction; blood; laparoscopy; physiology; prediction and forecasting; stomach bypass; time; Adult; Female; Gastric Bypass; Ghrelin; Humans; Insulin; Laparoscopy; Leptin; Male; Obesity, Morbid; Predictive Value of Tests; Time Factors; Weight Loss |
Appears in Collections: | 醫學系 |
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