https://scholars.lib.ntu.edu.tw/handle/123456789/541136
標題: | IL-1B-511 C-->T polymorphism is associated with increased host susceptibility to Helicobacter pylori infection in Chinese | 作者: | JYH-MING LIOU Lin J.-T. HSIU-PO WANG Huang S.-P. YI-CHIA LEE HAN-MO CHIU CHIA-TUNG SHUN MING-SHIANG WU |
公開日期: | 2007 | 卷: | 12 | 期: | 2 | 起(迄)頁: | 142-149 | 來源出版物: | Helicobacter | 摘要: | Background: The heritability of Helicobacter pylori infection from twin studies has been reported to be 0.66. However, few data were available on the host susceptibility to H. pylori infection in Chinese. We aimed to evaluate the impact of the IL-1B and IL-1RN single-nucleotide polymorphisms (SNP) and ABO blood types on the host susceptibility to H. pylori infection. Methods: Individuals who underwent routine health check-up were enrolled. Genotyping was assessed by polymerase chain reaction (PCR) followed by direct sequencing and size fractionation using DNA from peripheral blood samples. Odds ratios (OR) for the susceptibility of H. pylori infection were computed from logistic regression models. Results: The overall prevalence of H. pylori was 62% among the 663 healthy individuals, with 54.7, 63.5, and 66.9% in persons genotyped C/C, C/T, and T/T at IL-1B-511, respectively. Age (OR 1.05, 95% CI = 1.03-1.07, p <.001) and T carrier at IL-1B-511 (OR = 1.56, 95% CI = 1.06-2.30, p =.026) were independent factors associated with increased risks of H. pylori infection in the multivariate analysis. The risks of H. pylori infection were not related to IL-1RN SNP and ABO blood types. Conclusions: These findings support that a proinflammatory polymorphism at IL-1B promoter gene is associated with increased host susceptibility to H. pylori infection in Chinese. ? 2007 The Authors. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847070741&doi=10.1111%2fj.1523-5378.2007.00484.x&partnerID=40&md5=f7455b8f5f61d21793826c550677e64a https://scholars.lib.ntu.edu.tw/handle/123456789/541136 |
ISSN: | 1083-4389 | DOI: | 10.1111/j.1523-5378.2007.00484.x | SDG/關鍵字: | DNA; interleukin 1 receptor blocking agent; interleukin 1beta; interleukin 1beta 511; unclassified drug; adult; article; bacterial infection; blood group ABO system; blood sampling; Chinese; DNA sequence; female; fractionation; genotype; Helicobacter pylori; heterozygote; host susceptibility; human; infection sensitivity; logistic regression analysis; male; medical examination; multivariate analysis; polymerase chain reaction; prevalence; priority journal; promoter region; risk; single nucleotide polymorphism; ABO Blood-Group System; Adult; Asian Continental Ancestry Group; Female; Genetic Predisposition to Disease; Helicobacter Infections; Helicobacter pylori; Humans; Infant; Interleukin-1beta; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions (Genetics); Receptors, Interleukin-1; Regression Analysis; Rural Health; Taiwan; Urban Health; Helicobacter pylori |
顯示於: | 醫學系 |
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