https://scholars.lib.ntu.edu.tw/handle/123456789/541158
標題: | Cavernous transformation of the portal vein: Etiology determines the outcome | 作者: | Chang C.-Y. PEI-MING YANG Hung S.-P. WOEI TSAY Lin L.-C. Lin J.-T. HSIU-PO WANG |
公開日期: | 2006 | 卷: | 53 | 期: | 72 | 起(迄)頁: | 892-897 | 來源出版物: | Hepato-Gastroenterology | 摘要: | Background/Aims: Cavernous transformation of the portal vein is a rare condition with various etiologies and diverse clinical presentations. We aim to assess the disease outcome of different etiologic groups. Methodology: We retrospectively scrutinized the clinicopathologic characteristics of 35 patients with cavernous transformation of the portal vein, placing special emphasis on the disease extent, progression, and outcome after stratification into different etiologic groups. Results: There were 20 males and 15 females with a mean age of 40.4 years. The etiologies of these patients could be classified into four groups including hematologic disease (n=12, 34.2%), malignant disease (n=8, 22.9%), non-malignant disease (n=6, 17.2%), and idiopathic (n=9, 25.7%). The hematologie disease group had 9 patients with myeloproliferative disease and 3 patients with protein C or protein S deficiency. The hematologic disease group survived well after medication or surgical management. Hepatocellular carcinoma (n=6) was the leading cause in the malignant diseases group, which had a significantly poorer survival rate than the rest (p<0.05). Conclusions: Cavernous transformation of the portal vein is a long-term sequele of portal vein thrombosis in which the etiology determines the outcome. More aggressive management including long-term antieoagulation in patients with myeloproliferative disorder or underlying prothrombotic states and endoscopic therapy in controlling variceal bleeding may be a more effective treatment for these patients. ? H.G.E. Update Medical Publishing S.A. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33845222332&partnerID=40&md5=2b1873e9aeec08f297b5e174a7555220 https://scholars.lib.ntu.edu.tw/handle/123456789/541158 |
ISSN: | 0172-6390 | SDG/關鍵字: | anticoagulant agent; propranolol; warfarin; adult; article; bleeding; cancer survival; cavernous hemangioma; clinical article; clinical feature; controlled study; corpus cavernosum; disease association; disease course; esophagogastroduodenoscopy; female; follow up; hematologic disease; histopathology; human; idiopathic disease; laboratory test; liver cell carcinoma; male; malignant neoplastic disease; myeloproliferative disorder; portal vein; priority journal; protein C deficiency; protein S deficiency; shunting; splenectomy; Adult; Aged, 80 and over; Combined Modality Therapy; Female; Hepatic Vein Thrombosis; Humans; Male; Middle Aged; Portal Vein; Prognosis; Treatment Outcome |
顯示於: | 醫學系 |
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