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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/541281
Title: Lymphoepithelioma-like carcinoma of the stomach: A subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection
Authors: Wang H.-H.
MING-SHIANG WU 
CHIA-TUNG SHUN 
HSIU-PO WANG 
Lin C.-C.
Lin J.-T.
Issue Date: 1999
Journal Volume: 46
Journal Issue: 26
Start page/Pages: 1214-1219
Source: Hepato-Gastroenterology
Abstract: 
BACKGROUND/AIMS: To evaluate the clinicopathological features of lymphoepithelioma-like carcinoma of stomach in Taiwan. METHODOLOGY: Of 379 patients with gastric adenocarcinoma, from 1993 to 1996, 6 of them with lymphoepithelioma-like carcinoma of stomach were retrospectively studied. RESULTS: Five patients were females and one patient was male. Their age ranged from 51-75 years with a mean age of 61.5 years. Endoscopically, 2 patients were initially diagnosed as early gastric cancer and the other 4 were diagnosed as advanced gastric cancer. Three patients had tumors located in the lower third of the stomach, while the other three tumors were located in the middle and upper third. Two tumors invaded into the serosal layer and the other four lesions were confined at submucosal and muscular layers. Using the in situ hybridization method, all 6 patients (100%) had positive nuclear Epstein-Barr virus-encoded small RNA signals in the tumor cells but not in the surrounding lymphoid stroma and non-neoplastic gastric mucosa. Helicobacter pylori was found in 4 (66.7%) of the cases. The mean follow-up period of the 6 patients was 27 months. Five patients were free of the disease. Lymph node involvement and mesenteric implantation was noted in one patient in which cancer recurred 1 year after gastrectomy. CONCLUSIONS: Lymphoepithelioma-like carcinoma of stomach in this study revealed a female predominance, preferential localization in the proximal part of the stomach, better prognosis, and a high association with Epstein-Barr virus infection.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032904099&partnerID=40&md5=50948f27f48d84d686a320cf43457abd
https://scholars.lib.ntu.edu.tw/handle/123456789/541281
ISSN: 0172-6390
SDG/Keyword: nuclear RNA; adult; advanced cancer; aged; article; cancer localization; cancer recurrence; clinical article; early cancer; epstein barr virus; female; femininity; follow up; gastrointestinal endoscopy; helicobacter pylori; human; human tissue; in situ hybridization; lymphoepithelioma; lymphoma; male; mesentery tumor; priority journal; retrospective study; serosa; signal transduction; stomach carcinoma; stomach mucosa; stomach muscle; stomach tumor; submucosa; Taiwan; tumor cell; Aged; Carcinoma, Squamous Cell; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; Retrospective Studies; Stomach; Stomach Neoplasms; Taiwan; Tumor Virus Infections; Virulence
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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