Increased risk of ischemic heart disease in young patients with migraine: A population-based, propensity score-matched, longitudinal follow-up study
Journal
International Journal of Cardiology
Journal Volume
172
Journal Issue
1
Pages
213-216
Date Issued
2014
Author(s)
Abstract
Background The association between migraine and the risk of ischemic heart disease (IHD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether young migraineurs are at a higher risk of developing IHD. Methods A total of 11,541 subjects aged between 18 and 45 years with at least two ambulatory visits with the principal diagnosis of migraine in 2001 were enrolled in the migraine group. We used a logistic regression model that included age, sex, pre-existing comorbidities, and socioeconomic status as covariates to compute the propensity score. The non-migraine group consisted of 11,541 propensity score-matched, randomly sampled subjects without migraine. The 3-year IHD-free survival rate and the cumulative incidence of IHD were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched by propensity score was used to estimate the effect of migraine on the risk of developing subsequent IHD. Results The mean age in both groups was 32.3 years. During follow-up, 121 subjects in the migraine group and 55 in the non-migraine group developed IHD. The incidence rate of IHD was 4.56 (95% confidence interval [CI], 3.78 to 5.44) per 1000 person-years in the migraine group and 2.00 (95% CI, 1.51 to 2.61) per 1000 person-years in the non-migraine group. Compared to the non-migraine group, the HR of IHD for the migraine group was 2.50 (95% CI, 1.78 to 3.52, P < 0.0001). Conclusions This study showed an increased risk of developing IHD in young patients with newly diagnosed migraine. ? 2014 Elsevier Ireland Ltd.
SDGs
Other Subjects
adolescent; adult; female; follow up; human; incidence; Kaplan Meier method; longitudinal study; male; middle aged; Migraine Disorders; Myocardial Ischemia; propensity score; proportional hazards model; risk factor; statistical model; young adult; Adolescent; Adult; Female; Follow-Up Studies; Humans; Incidence; Kaplan-Meier Estimate; Logistic Models; Longitudinal Studies; Male; Middle Aged; Migraine Disorders; Myocardial Ischemia; Propensity Score; Proportional Hazards Models; Risk Factors; Young Adult
Type
journal article