https://scholars.lib.ntu.edu.tw/handle/123456789/541877
標題: | Parkinson disease and risk of acute myocardial infarction: A population-based, propensity score-matched, longitudinal follow-up study | 作者: | HUEY-WEN LIANG YA-PING HUANG SHIN-LIANG PAN |
公開日期: | 2015 | 出版社: | Mosby Inc. | 卷: | 169 | 期: | 4 | 起(迄)頁: | 508-514 | 來源出版物: | American Heart Journal | 摘要: | Objectives Previous studies on the risk of acute myocardial infarction (AMI) in patients with Parkinson disease (PD) have generated inconsistent results. The purpose of this population-based longitudinal follow-up study was to investigate whether incident PD is associated with an increased risk of AMI. Methods A total of 3,211 subjects with at least 2 ambulatory visits with the principal diagnosis of PD in 2001 were enrolled in the PD group. The non-PD group consisted of 3,211 propensity score-matched subjects without PD. The propensity scores were computed using a logistic regression model that included age, sex, preexisting comorbidities, and socioeconomic status. The 3-year AMI-free survival rates of the 2 groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched by propensity score was used to estimate the effect of PD on subsequent occurrence of AMI. Results During the 3-year follow-up period, 83 subjects in the PD group and 53 in the non-PD group developed AMI (either fatal or nonfatal) events. The hazard ratio of AMI for the PD group compared with the non-PD group was 1.67 (95% CI 1.15-2.41, P =.0067). The AMI-free survival rate of the PD group was significantly lower than that of the non-PD group (P =.0032). The hazard ratios associated with PD for the combined end point 1 (AMI or cardiovascular death) and combined end point 2 (AMI or all-cause death) were 1.46 (95% CI 1.14-1.88, P =.0029) and 1.42 (95% CI 1.24-1.64, P <.0001), respectively. Conclusions This study shows that PD is related to an increased risk of AMI. Further studies are required to investigate the mechanism underlying this association. ? 2014 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927568369&doi=10.1016%2fj.ahj.2014.11.018&partnerID=40&md5=e768931653917a88d43c32f3392bfc4e https://scholars.lib.ntu.edu.tw/handle/123456789/541877 |
ISSN: | 0002-8703 | DOI: | 10.1016/j.ahj.2014.11.018 | SDG/關鍵字: | amantadine; biperiden; bromocriptine; entacapone; levodopa; pergolide; ropinirole; selegiline; trihexyphenidyl; acute heart infarction; aged; Article; brain degeneration; cardiovascular risk; cohort analysis; comorbidity; extrapyramidal syndrome; female; follow up; human; longitudinal study; major clinical study; male; motor dysfunction; Parkinson disease; priority journal; propensity score; social status; survival rate; cause of death; clinical trial; complication; health survey; incidence; multicenter study; Myocardial Infarction; Parkinson disease; procedures; prognosis; retrospective study; risk assessment; risk factor; Taiwan; trends; Aged; Cause of Death; Female; Follow-Up Studies; Humans; Incidence; Male; Myocardial Infarction; Parkinson Disease; Population Surveillance; Prognosis; Propensity Score; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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