Does Adhesive Capsulitis of the Shoulder Increase the Risk of Stroke? A Population-Based Propensity Score-Matched Follow-Up Study
Journal
PLoS ONE
Journal Volume
7
Journal Issue
11
Pages
e49343
Date Issued
2012
Author(s)
Abstract
Objectives: A previous population-based study reported an increased risk of stroke after the occurrence of adhesive capsulitis of the shoulder (ACS), but there were substantial imbalances in the distribution of age and pre-existing vascular risk factors between subjects with ACS and without ACS, which might lead to a confounded association between ACS and stroke. The purpose of the present large-scale propensity score-matched population-based follow-up study was to clarify whether there is an increased stroke risk after ACS. Methods: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 22025 subjects with at least two ambulatory visits with the principal diagnosis of ACS in 2001 was enrolled in the ACS group. The non-ACS group consisted of 22025, propensity score-matched subjects without ACS. The stroke-free survival curves for these 2 groups were compared using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of ACS on the occurrence of stroke. Results: During the two-year follow-up period, 657 subjects in the ACS group (2.98%) and 687 in the non-ACS group (3.12%) developed stroke. The hazard ratio (HR) of stroke for the ACS group was 0.93 compared to the non-ACS group (95% confidence interval [CI], 0.83-1.04, P = 0.1778). There was no statistically significant difference in stroke subtype distribution between the two groups (P = 0.2114). Conclusions: These findings indicate that ACS itself is not associated with an increased risk of subsequent stroke. ? 2012 Wu et al.
SDGs
Other Subjects
adult; age; aged; article; brain hemorrhage; brain ischemia; cerebrovascular accident; comorbidity; diabetes mellitus; disease association; disease classification; female; human; humeroscapular periarthritis; hyperlipidemia; hypertension; income; ischemic heart disease; Kaplan Meier method; logistic regression analysis; major clinical study; male; propensity score; proportional hazards model; rheumatic heart disease; risk assessment; sex; social status; Taiwan; Adult; Aged; Aged, 80 and over; Bursitis; Comorbidity; Female; Follow-Up Studies; Humans; Male; Middle Aged; Propensity Score; Proportional Hazards Models; Risk Factors; Shoulder; Stroke; Survival Rate; Taiwan
Type
journal article