https://scholars.lib.ntu.edu.tw/handle/123456789/542085
標題: | Characteristics of arsenic-related bladder cancer: A study from Nationwide Cancer Registry Database in Taiwan | 作者: | Yeh T.-C. Tai Y.-S. YEONG-SHIAU PU CHUNG-HSIN CHEN |
公開日期: | 2015 | 出版社: | Elsevier B.V. | 卷: | 26 | 期: | 2 | 起(迄)頁: | 103-108 | 來源出版物: | Urological Science | 摘要: | Objective: To investigate the clinical and pathological characteristics of arsenic-related bladder cancer. Methods: From 2008 through 2011, data on 7699 patients with bladder cancer were extracted from the Taiwan Cancer Registry Database. A diagnosis of bladder cancer (International Statistical Classification of Diseases and Related Health Problems, 9th Revision: 188) was confirmed in all patients. Using birth residency codes, patients were divided into three groups: the core zone (CZ; an arsenic endemic area with well water arsenic levels of 350-1100ng/mL); zone 1 (Z1; an area with well water arsenic levels of?350ng/mL but not a blackfoot disease-endemic area); and zone 2 (Z2; an area with well water arsenic levels of<350ng/mL). Clinicopathological characteristics and survival outcomes were compared between the three groups. Results: In this cohort, 119 (1.5%), 1145 (14.9%), and 6435 (83.6%) patients were born in the CZ, Z1, and Z2, respectively. A higher proportion of female patients (35.3%, 31.4%, and 27.5%; p=0.014) and lower smoking rates (29%, 34.8%, and 35.9%; p=0.694) were noted in the CZ compared with Z1 and Z2. CZ patients had more high-grade differentiated (80.9%, 69.9%, and 63.0%; p<0.001) and high clinical stage (stages II-IV, 52.8%, 38.1%, and 31.8%; p<0.001) tumors compared with Z1 and Z2 patients. Radical cystectomy was infrequently performed for clinical stage II (19.6%) and stage III (25.2%) bladder cancer patients. CZ patients had significantly shorter overall and cancer-specific survival durations compared with Z1 and Z2 patients. Older age, female sex, higher tumor grade or stage, and higher arsenic levels were associated with both poorer overall and cancer-specific survival in a multivariate analysis with a Cox proportional model. Conclusion: In Taiwan, patients with arsenic-related bladder cancer may have poorer tumor characteristics and decreased overall and cancer-specific survival rates. ? 2015. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84937513959&doi=10.1016%2fj.urols.2015.05.002&partnerID=40&md5=4079b5986fe2a49aca62c61e8a9120a6 https://scholars.lib.ntu.edu.tw/handle/123456789/542085 |
ISSN: | 1879-5226 | DOI: | 10.1016/j.urols.2015.05.002 | SDG/關鍵字: | arsenic; adult; age distribution; aged; arsenic pollution; Article; bladder cancer; cancer grading; cancer radiotherapy; cancer registry; cancer staging; cancer survival; controlled study; cystectomy; environmental exposure; female; human; major clinical study; male; middle aged; overall survival; pollution; priority journal; sex ratio; smoking; survival rate; Taiwan; transurethral resection; treatment response; very elderly |
顯示於: | 醫學系 |
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