|Title:||Clinical Outcome of Taiwanese Men With Metastatic Prostate Cancer Compared With Other Ethnic Groups||Authors:||CHUNG-HSIN CHEN
|Issue Date:||2008||Journal Volume:||72||Journal Issue:||6||Start page/Pages:||1287-1292||Source:||Urology||Abstract:||
Objectives: Prostate cancer incidence varies significantly among different ethnic groups. However, little is known about the survival outcome among groups. We sought to compare the survival outcome in patients with metastatic prostate cancer among different ethnic groups and to identify independent prognostic factors affecting overall survival in Taiwanese patients. Methods: From January 1996 to February 2005, 482 men with newly diagnosed metastatic prostate adenocarcinoma were enrolled from five major medical centers in Taiwan. The cohort accounted for about 11.5% of all patients with metastatic disease during the period in Taiwan. The demographics, tumor characteristics, and survival outcome were compared with several published Western and Japanese series. Five series were selected from MEDLINE: the Southwest Oncology Group; Detroit Metropolitan Surveillance, Epidemiology, and End Results Program Registry; American College of Surgeons; National Cancer Registry in Sweden; and Gurma and Nagasaki University Group in Japan. Results: The Taiwanese patients were the oldest among the selected series. The median overall survival of our patients was 38.4 months (95% confidence interval 33 to 45 months), which was longer than that in the Western series (median 25 to 32 months) and similar to those in the Japanese series (median 36 months). In a multivariate analysis with age adjustment, bone pain, Gleason score 8 or greater, and visceral metastases independently predicted a reduced overall survival in our series compared with each favorable strata (hazard ratio 2.22, 1.96, and 1.51, respectively; all P <0.05). Conclusions: Taiwanese men with metastatic prostate cancer might have a better survival compared with Western men. ? 2008 Elsevier Inc. All rights reserved.
|ISSN:||0090-4295||DOI:||10.1016/j.urology.2008.01.026||SDG/Keyword:||adult; aged; article; bone pain; cancer diagnosis; cancer survival; controlled study; disease registry; ethnic difference; ethnic group; Gleason score; human; Japanese; major clinical study; male; metastasis; multivariate analysis; priority journal; prognosis; prostate adenocarcinoma; Taiwan; Adult; Age Factors; Aged; Aged, 80 and over; Ethnic Groups; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Metastasis; Prostate-Specific Antigen; Prostatic Neoplasms; Retrospective Studies; Taiwan; Treatment Outcome
|Appears in Collections:||醫學系|
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