https://scholars.lib.ntu.edu.tw/handle/123456789/542160
標題: | Immunopathogenesis of systemic lupus erythematosus and rheumatoid arthritis: the role of aberrant expression of non-coding RNAs in T cells | 作者: | Lai N.-S. Koo M. CHIA-LI YU Lu M.-C. |
關鍵字: | non-coding RNAs; rheumatoid arthritis; systemic lupus erythematosus; T lymphocytes | 公開日期: | 2017 | 出版社: | Blackwell Publishing Ltd | 卷: | 187 | 期: | 3 | 起(迄)頁: | 327-336 | 來源出版物: | Clinical and Experimental Immunology | 摘要: | Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are RNA molecules that do not translate into protein. Both miRNAs and lncRNAs are known to regulate gene expression and to play an essential role in T cell differentiation and function. Both systemic lupus erythematosus (SLE), a prototypic systemic autoimmune disease, and rheumatoid arthritis (RA), a representative disease of inflammatory arthritis, are characterized by a complex dysfunction in the innate and adaptive immunity. T cells play a central role in cell-mediated immune response and multiple defects in T cells from patients with SLE and RA have been observed. Abnormality in T cell signalling, cytokine and chemokine production, T cell activation and apoptosis, T cell differentiation and DNA methylation that are associated closely with the aberrant expression of a number of miRNAs and lncRNAs have been implicated in the immunopathogenesis of SLE and RA. This review aims to provide an overview of the current state of research on the abnormal expression of miRNAs and lncRNAs in T cells and their roles in the immunopathogenesis of SLE and RA. In addition, by comparing the differences in aberrant expression of miRNAs and lncRNAs in T cells between patients with SLE and RA, controversial areas are highlighted that warrant further investigation. ? 2016 British Society for Immunology |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009485623&doi=10.1111%2fcei.12903&partnerID=40&md5=a12e8dcc2df936ded4deb91eda8daf70 https://scholars.lib.ntu.edu.tw/handle/123456789/542160 |
ISSN: | 0009-9104 | DOI: | 10.1111/cei.12903 | SDG/關鍵字: | chemokine; cytokine; long untranslated RNA; microRNA; untranslated RNA; microRNA; untranslated RNA; cytokine production; cytokine release; gene expression; genetic transcription; human; immunogenetics; immunopathogenesis; intracellular signaling; nonhuman; priority journal; Review; rheumatoid arthritis; systemic lupus erythematosus; T lymphocyte; T lymphocyte subpopulation; adaptive immunity; animal; apoptosis; DNA methylation; genetics; immunology; lymphocyte activation; pathology; rheumatoid arthritis; systemic lupus erythematosus; T lymphocyte; Adaptive Immunity; Animals; Apoptosis; Arthritis, Rheumatoid; DNA Methylation; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; MicroRNAs; RNA, Untranslated; T-Lymphocytes |
顯示於: | 醫學系 |
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