https://scholars.lib.ntu.edu.tw/handle/123456789/542189
標題: | The alteration of placental-derived soluble MHC class I chain-related protein A and B during pregnancy | 作者: | Huang S.-Y. Chiang C.-H. Chen F.-P. CHIA-LI YU |
關鍵字: | Amniotic fluid; Immune evasion; Parturition; Pregnancy; Soluble MHC class I chain-related proteins A and B | 公開日期: | 2011 | 卷: | 90 | 期: | 7 | 起(迄)頁: | 802-807 | 來源出版物: | Acta Obstetricia et Gynecologica Scandinavica | 摘要: | Objective. According to a novelmechanism for fetal evasion from maternal immune attack via the engagement and down-regulation of the maternal natural killer cell receptor NKG2D by soluble MHC class I chain-related proteins (sMIC) A and B derived from placenta, we aimed to measure whether the sMICA/B level altered during pregnancy. Design and Setting.Healthy women undergoing routine antepartum examination at Kee-Lung Chang Gung Memorial Hospital from December 2006 to December 2007 were prospectively registered for this study. Samples. We collected 337 serum specimens and 10 amniotic fluid samples from 300 normal pregnant women for sMICA/B analysis. Methods. Capture ELISA procedures were used to determine sMICA/B concentration in serum and amniotic fluid specimens. Main Outcome Measures. We hypothesized that the sMICA/B level would increase in proportion to the gestational age to protect the fetus from maternal immune rejection in the normal pregnancy. Results. The serum sMICA/B level rose gradually with the progression of gestation and decreased after the second trimester, with the lowest level appearing before delivery. In addition, we found that levels of soluble MICA/B were extremely low in amniotic fluid. Conclusions.We suggest that, as delivery approaches, the reduced production of soluble MICA/B by the aged placenta may be playing a role in parturition. Furthermore, we suggest that the effect of solubleMICA/B on natural killer cells of pregnant women is limited to the maternal placental surface, but not transferred through the placenta into the amniotic cavity. ? 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica ? 2011 Nordic Federation of Societies of Obstetrics and Gynecology. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959815632&doi=10.1111%2fj.1600-0412.2011.01131.x&partnerID=40&md5=62cb78caf92febee0ebdddac3da38230 https://scholars.lib.ntu.edu.tw/handle/123456789/542189 |
ISSN: | 0001-6349 | DOI: | 10.1111/j.1600-0412.2011.01131.x | SDG/關鍵字: | major histocompatibility antigen class 1; mhc class 1 chain related protein a; mhc class 1 chain related protein b; natural killer cell receptor NKG2D; unclassified drug; adult; amnion fluid; article; birth; blood sampling; controlled study; delivery; enzyme linked immunosorbent assay; female; gestational age; human; major clinical study; maternal serum; placenta; pregnancy; pregnant woman; prenatal care; priority journal; prospective study; second trimester pregnancy; Adult; Amniotic Fluid; Cohort Studies; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Fetal Development; Gestational Age; Histocompatibility Antigens Class I; Humans; Placenta; Pregnancy; Prenatal Care; Prospective Studies; Reference Values; Solubility; Taiwan |
顯示於: | 醫學系 |
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