https://scholars.lib.ntu.edu.tw/handle/123456789/542712
標題: | Exposure to fine particulate matter (PM2.5) and pediatric rheumatic diseases | 作者: | Wang, C.-M. Jung, C.-R. WEI-TING CHEN Hwang, Bing-Fang |
公開日期: | 2020 | 卷: | 138 | 起(迄)頁: | - | 來源出版物: | Environment International | 摘要: | Few studies have assessed the association between fine particulate matter (PM2.5) exposure during pregnancy and infancy and pediatric rheumatic diseases (PRDs). The goal of this study was to investigate the association of PM2.5 with PRDs, and to explore sensitive windows of exposure. Therefore, we conducted a cohort-based case-control study to investigate the association between weekly exposure to PM2.5 and PRDs in Taiwan. Our birth cohort consisted of infants born in 2004–2014 (n = 1,991,592) who were followed from conception to the end of 2015. There were 2363 cases of incident PRDs in children, and 23,630 children served as controls using density matching (1:10) based on date of birth, gender, and gestational week. We used a linear mixed effect (LME) model to incorporate the aerosol optical depth (AOD), meteorological variables, and land-use data to predict daily PM2.5 concentrations. We also performed conditional logistic regression with distributed lag non-linear models (DLNMs) to assess the effects of weekly average PM2.5 on PRDs, as well as dose-response relationships. In DLNMs, exposure to PM2.5 during pregnancy (11–40 weeks) or infancy (1–14 weeks after birth) was associated with incident PRDs adjusting for potential confounding factors, and for carbon monoxide and sulfur dioxide. In the dose-response association, the odds ratios of PRDs were significantly increased for PM2.5 exposures between 26 and 54 μg/m3. In addition, exposure to PM2.5 above 81 μg/m3 dramatically increased the risk of PRDs. In conclusions, our study provides new data to suggest that PM2.5 exposure from 11–40 gestational weeks to 1–14 weeks after birth can increase the risk for PRDs in a non-linear dose-response fashion. © 2020 The Authors |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85080027854&partnerID=40&md5=0d659848e6ae3e0b1c8cef15dc1a2828 https://scholars.lib.ntu.edu.tw/handle/123456789/542712 |
DOI: | 10.1016/j.envint.2020.105602 | SDG/關鍵字: | Carbon monoxide; Disease control; Land use; Logistic regression; Obstetrics; Particles (particulate matter); Pediatrics; Sulfur dioxide; Autoimmune; Case-control study; Conditional logistic regressions; Dose response relationships; Estimation models; Fine particulate matter (PM2.5); Meteorological variables; PM2.5; Diseases; carbon monoxide; sulfur dioxide; bone; child; cohort analysis; disease; dose-response relationship; numerical model; particulate matter; pollution exposure; pregnancy; regression analysis; adult; aerosol optical depth; age; Article; birth; case control study; cohort analysis; concentration (parameter); confounding variable; controlled study; disease association; environmental exposure; environmental parameters; female; gestational age; human; infancy; infant; land use; major clinical study; meteorological phenomena; particulate matter; pediatrics; prediction; pregnancy; priority journal; rheumatic disease; Taiwan; adolescent; adverse event; air pollutant; air pollution; analysis; child; epidemiology; maternal exposure; particulate matter; toxicity; Taiwan; Adolescent; Air Pollutants; Air Pollution; Case-Control Studies; Child; Female; Humans; Infant; Maternal Exposure; Particulate Matter; Pregnancy; Rheumatic Diseases; Taiwan |
顯示於: | 大氣科學系 |
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