https://scholars.lib.ntu.edu.tw/handle/123456789/543016
標題: | Planarian mobility assay as a simple alternative for rapid screening aquatic acute toxicity of personal care products | 作者: | Li, M.-H. MEI - HUI LI |
公開日期: | 2020 | 卷: | 29 | 期: | 5 | 起(迄)頁: | 3362-3369 | 來源出版物: | Fresenius Environmental Bulletin | 摘要: | The effects of 25 chemicals used in personal care products, including benzophenone-type UV filters, paraben preservatives, and surfactants, on freshwater planarian locomotion were examined using an automated video tracking system during the second 5-min period exposure. The slope of the linear regression for second 5-min EC5o and 24-h median lethal concentration (LC50 ) was 0.9904. The second 5-min EC50 values of planarian mobility were similar to their corresponding 24-h LC50 values. The results suggest that changes in mobility velocity in planarians can serve as a rapid acute aquatic toxicity indicator. Moreover, planarian mobility assay can be a useful tool in preliminary evaluation of water samples and in deciding the timely precautionary measures required to prevent episodic water pollution, even in the absence of acute aquatic toxicity information. Based on the result of this study, planarian mobility assay provides great advantages to promote 3Rs principle in toxicology study, by replacing vertebrates to invertebrates, reducing numbers of experimental animals used, and refining animals by greatly increased survival and recovery. © 2020 Parlar Scientific Publications. All rights reserved. |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85091923281&partnerID=40&md5=ee3c9c4e7d7f60c81540f64431d8b5c1 https://scholars.lib.ntu.edu.tw/handle/123456789/543016 |
SDG/關鍵字: | bioassay; concentration (composition); locomotion; mobility; paraben; PPCP; regression analysis; survival; toxicity; toxicology; tracking; water pollution; Animalia; Invertebrata; Planaria; Turbellaria; Vertebrata |
顯示於: | 地理環境資源學系 |
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