https://scholars.lib.ntu.edu.tw/handle/123456789/543585
標題: | Fibrosing cholestatic hepatitis in a hepatitis B surface antigen carrier after renal transplantation | 作者: | CHIEN-HUNG CHEN PEI-JER CHEN Chu J.-S. KUN-HUEI YEH Lai M.-Y. DING-SHINN CHEN |
公開日期: | 1994 | 卷: | 107 | 期: | 5 | 起(迄)頁: | 1514-1518 | 來源出版物: | Gastroenterology | 摘要: | A 45-year-old hepatitis B surface antigen carrier had an allograft kidney transplantation and maintenance immunosuppression with cyclosporin A and predniso-lone. Six months later, she experienced a rapidly progressive hepatic failure manifested by elevation of serum bilirubin level, prolongation of prothrombin time, and mild to modest increase of serum aminotransferase levels. She died in 6 weeks. Postmortem liver histology showed canalicular and cellular cholestasis and ground-glass appearance and ballooning of most hepatocytes, but only mild inflammatory cell infiltration. Immunohistochemical staining showed massive loads of hepatitis B surface and core antigens in the hepatocytes and extensive periportal fibrosis. The whole picture was compatible with fibrosing cholestatic hepatitis described in hepatitis B virus-infected liver transplant. Sequencing of the hepatitis B virus genome amplified from the patient's serum indicated a precore mutant but few mutations in the core, pre-S, and S genes. Little inflammatory reaction was observed histologically despite HLA compatibility, a situation differing from that in liver transplant. This observation indicates that fibrosing cholestatic hepatitis may also occur in non-liver transplant setting. ? 1994. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027973405&doi=10.1016%2f0016-5085%2894%2990557-6&partnerID=40&md5=519d3e40470b1bde67f0b662afc73248 https://scholars.lib.ntu.edu.tw/handle/123456789/543585 |
ISSN: | 0016-5085 | DOI: | 10.1016/0016-5085(94)90557-6 | SDG/關鍵字: | adult; article; case report; cholestatic hepatitis; female; hepatitis B; human; immunosuppressive treatment; kidney graft; kidney transplantation; liver failure; pathogenesis; postoperative complication; priority journal |
顯示於: | 腫瘤醫學研究所 |
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