https://scholars.lib.ntu.edu.tw/handle/123456789/543733
標題: | Radical Cystectomy in the Treatment of Bladder Cancer: Oncological Outcome and Survival Predictors | 作者: | Ho C.-H. CHAO-YUAN HUANG WEI-CHOU LIN SHIH-CHIEH CHUEH YEONG-SHIAU PU Lai M.-K. HONG-JENG YU KUO-HOW HUANG |
公開日期: | 2009 | 卷: | 108 | 期: | 11 | 起(迄)頁: | 872-878 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: To better understand the result of radical cystectomy in the treatment of bladder cancer, we analyzed our data and reported the oncological outcomes and survival predictors. Methods: Patients underwent radical cystectomy for bladder transitional cell carcinoma between March 1995 and July 2007 were evaluated. The clinical course, pathological characteristics, and clinical outcomes were described and analyzed. Results: A total of 148 patients (98 men and 50 women) with a median age of 66.7 years (range: 23.8-83.3) were included in the study. Median follow-up was 64 months. The perioperative mortality was 2.7%. The 5-year recurrence-free survival (RFS) and overall survival (OS) for all 148 patients was 61% and 53%, respectively. The 5-year RFS and OS were 68% and 62% for pT2, 65% and 59% for pT3, 11% and 9% for pT4, and 37% and 31% for nodal-positive disease, respectively. The number of positive lymph nodes was significantly associated with survival: 5-year RFS and OS were 54% and 33%, for patients with only 1-3 positive lymph nodes, whereas, all patients with ?4 positive lymph nodes had recurrence. On multivariate analysis, age > 60 years, pT4 tumors, and lymph node involvement had a negative impact on survival. Conclusion: Radical cystectomy can be curative in a significant portion of patients with organ-confined (T2 or less) and extravesical (pT3) bladder cancer. Age > 60 years, pT4 tumors, and nodal metastases were associated with poor prognosis. Patients with limited lymph node involvement (1-3 nodes) can be cured by surgery alone, whereas a more extensive lymph node metastasis (? 4 nodes) eventually results in recurrence. Concomitant prostate cancer is of low grade and early stage, and is clinically insignificant. ? 2009 Formosan Medical Association & Elsevier. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71649087105&doi=10.1016%2fS0929-6646%2809%2960419-8&partnerID=40&md5=76af6cf9bbaf66035f514ff6975ad5d5 https://scholars.lib.ntu.edu.tw/handle/123456789/543733 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60419-8 | SDG/關鍵字: | adult; aged; article; bladder carcinoma; cancer mortality; cancer survival; cystectomy; female; human; lymph node metastasis; major clinical study; male; outcome assessment; overall survival; prediction; prognosis; prostate cancer; recurrence risk; Adult; Aged; Aged, 80 and over; Cystectomy; Female; Humans; Male; Middle Aged; Retrospective Studies; Urinary Bladder Neoplasms |
顯示於: | 醫學系 |
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