https://scholars.lib.ntu.edu.tw/handle/123456789/543831
標題: | Association of lower urinary tract symptoms and OAB severity with quality of life and mental health in China, Taiwan and South Korea: Results from a cross-sectional, population-based study | 作者: | Lee K.-S. Yoo T.K. Liao L. Wang J. Chuang Y.-C. SHIH-PING LIU Chu R. Sumarsono B. |
關鍵字: | Asia; Epidemiology; Lower urinary tract symptoms; Mental health; Prevalence; Quality of life | 公開日期: | 2017 | 出版社: | BioMed Central Ltd. | 卷: | 17 | 期: | 1 | 起(迄)頁: | 108 | 來源出版物: | BMC Urology | 摘要: | Background: Lower urinary tract symptoms (LUTS) and overactive bladder (OAB) symptoms have a substantial effect on quality of life (QoL). We report QoL and mental health results from a LUTS prevalence study in three Asian countries. Methods: A cross-sectional, population-representative, internet-based study among individuals aged ?40 years in China, Taiwan and South Korea. Instruments included: Overactive Bladder Symptom Score (OABSS); International Prostate Symptom Score (IPSS); other International Continence Society (ICS) symptom questions; health-related QoL 12-item short-form (HRQoL-SF12v2); Work Limitations Questionnaire (WLQ); Hospital Anxiety and Depression Scale (HADS). Presence of LUTS was determined according to ICS criteria, with three symptom groups (storage, voiding and post-micturition). Post-stratification weighting matched the age and sex population distribution per country. Initial data analyses were based on descriptive statistics. Significance testing undertaken post hoc included: independent-samples t-test (differences in HRQoL between sexes and between individuals with/without LUTS; relationship between HRQoL score and OABSS; differences in HADS anxiety and depression scores between individuals with/without LUTS; association between HADS anxiety/depression scores and OABSS), chi-square test (association between LUTS prevalence and workplace productivity) and analysis of variance (differences in HRQoL score and in HADS anxiety/depression scores between individuals with different symptom groups, association between HADS anxiety/depression scores and IPSS). Results: In total, 8284 participants were included. HRQoL scores were significantly worse (p < 0.001) among individuals with versus without LUTS (ICS criteria): mean physical health domain scores were 61.1 (standard deviation [SD], 20.1) and 76.7 (17.0), respectively; corresponding mental health domain scores were 34.8 (12.7) and 43.7 (10.7). Workplace productivity was best among individuals without LUTS (difficulties reported by 2-3% of individuals), and worst in those with all three ICS symptom groups (difficulties reported by 29-38% of individuals; p = 0.001). Mean HADS scores showed significantly worse (p < 0.001) levels of anxiety and depression among individuals with versus without LUTS: anxiety, 6.5 (SD, 3.7) and 4.0 (3.3); corresponding mean depression scores were 6.8 (4.3) and 4.2 (3.6). Increasing OAB severity was also associated with decreasing HRQoL physical and mental health scores. Conclusion: LUTS and increasing OAB severity are both associated with impaired QoL, reduced workplace productivity, and increased tendency towards anxiety and depression. These results highlight the need to ensure that individuals with LUTS receive appropriate, effective treatment. Trial registration: ClinicalTrials.gov identifier: NCT02618421, registered 26 November 2015 (retrospectively registered). ? 2017 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034786876&doi=10.1186%2fs12894-017-0294-3&partnerID=40&md5=60e9cd06c26e1342914a2fc67bfe1cb3 https://scholars.lib.ntu.edu.tw/handle/123456789/543831 |
ISSN: | 1471-2490 | DOI: | 10.1186/s12894-017-0294-3 | SDG/關鍵字: | adult; age; anxiety; Article; China; cross-sectional study; depression; descriptive research; disease association; disease severity; female; Hospital Anxiety and Depression Scale; human; lower urinary tract symptom; major clinical study; male; mental health; micturition; overactive bladder; population research; productivity; quality of life; retrospective study; South Korea; Taiwan; workplace; aged; depression; middle aged; psychology; Adult; Aged; Anxiety; China; Cross-Sectional Studies; Depression; Efficiency; Female; Humans; Lower Urinary Tract Symptoms; Male; Mental Health; Middle Aged; Quality of Life; Republic of Korea; Taiwan; Urinary Bladder, Overactive |
顯示於: | 醫學系 |
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