Neurotrophic keratitis in autoimmune polyglandular syndrome type 1: a case report
Journal
BMC ophthalmology
Journal Volume
21
Journal Issue
1
Date Issued
2021-01-07
Author(s)
Abstract
Autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive disease. In patients with APS-1, the most frequently reported ocular manifestations are keratoconjunctivitis with dry eye and retinal degeneration. However, to our knowledge, no research studies have reported the relationship between APS-1 and neurotrophic keratitis (NK). Possible explanations such as limbus cell deficiency being the primary cause of APS-1 keratopathy are not applicable to our unusual case of the patient with APS-1 presenting as ocular surface disease with NK. Our case findings suggest a new explanation for the observed corneal pathology and a potential treatment for these patients.
Subjects
Autoimmune polyglandular syndrome type 1 (APS-1); Case report; In vivo confocal microscopy; Neurotrophic keratitis
SDGs
Other Subjects
adult; case report; complication; cornea; dry eye; female; hereditary corneal dystrophy; human; keratitis; polyendocrinopathy; Adult; Cornea; Corneal Dystrophies, Hereditary; Dry Eye Syndromes; Female; Humans; Keratitis; Polyendocrinopathies, Autoimmune
Type
journal article