https://scholars.lib.ntu.edu.tw/handle/123456789/544018
Title: | Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid | Authors: | SHUO-MENG WANG Lai M.-N. Wei A. Chen Y.-Y. YEONG-SHIAU PU PAU-CHUNG CHEN Wang J.-D. |
Issue Date: | 2014 | Journal Volume: | 9 | Journal Issue: | 8 | Start page/Pages: | e105218 | Source: | PLoS ONE | Abstract: | Introduction: Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population. The objective of this study was to determine the risk of UC associated with AA-related Chinese herbal products among ESRD patients. Methods: We conducted a cohort study using the National Health Insurance reimbursement database to enroll all ESRD patients in Taiwan from 1998-2002. Cox regression models were constructed and hazard ratios and confidence intervals were estimated after controlling for potential confounders, including age, sex, residence in region with endemic black foot disease, urinary tract infection, and use of non-steroidal anti-inflammatory drugs and acetaminophen. Results: A total of 38,995 ESRD patients were included in the final analysis, and 320 patients developed UC after ESRD. Having been prescribed Mu Tong that was adulterated with Guan Mu Tong (Aristolochia manshuriensis) before 2004, or an estimated consumption of more than 1-100 mg of aristolochic acid, were both associated with an increased risk of UC in the multivariable analyses. Analgesic consumption of more than 150 pills was also associated with an increased risk of UC, although there was little correlation between the two risk factors. Conclusion: Consumption of aristolochic acid-related Chinese herbal products was associated with an increased risk of developing UC in ESRD patients. Regular follow-up screening for UC in ESRD patients who have consumed Chinese herbal products is thus necessary. ? 2014 Wang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929507677&doi=10.1371%2fjournal.pone.0105218&partnerID=40&md5=1a448148c6aa524c8828b5eada7bd75c https://scholars.lib.ntu.edu.tw/handle/123456789/544018 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0105218 | SDG/Keyword: | aristolochic acid; herbaceous agent; nonsteroid antiinflammatory agent; paracetamol; aristolochic acid; aristolochic acid I; herbaceous agent; adult; age; aged; article; blackfoot disease; cancer risk; cancer susceptibility; cohort analysis; data base; disease association; drug use; end stage renal disease; endemic disease; female; gender; human; major clinical study; male; national health insurance; prescription; reimbursement; residential area; risk assessment; Taiwan; urinary tract cancer; urinary tract infection; urothelial cancer; chemically induced; complication; incidence; Kidney Failure, Chronic; middle aged; risk factor; Urologic Neoplasms; very elderly; Aged; Aged, 80 and over; Aristolochic Acids; Cohort Studies; Drugs, Chinese Herbal; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Risk Factors; Taiwan; Urologic Neoplasms |
Appears in Collections: | 醫學系 |
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