https://scholars.lib.ntu.edu.tw/handle/123456789/544022
標題: | Increased upper and lower tract Urothelial carcinoma in patients with end-stage renal disease: A nationwide cohort study in Taiwan during 1997-2008 | 作者: | SHUO-MENG WANG Lai M.-N. PAU-CHUNG CHEN YEONG-SHIAU PU Lai M.-K. Hwang J.-S. Wang J.-D. |
公開日期: | 2014 | 出版社: | Hindawi Publishing Corporation | 卷: | 2014 | 起(迄)頁: | 149750 | 來源出版物: | BioMed Research International | 摘要: | Background. Urothelial cancer (UC) is the leading cancer of patients with end-stage renal disease (ESRD) in Taiwan. The aims of this study were to explore the time trends of UC incidences and propose possible etiologic factors. Methods. Abstracting from the National Health Insurance Research Database (NHIRD), there were 90,477 newly diagnosed cases of ESRD between 1997 and 2008 covering the patients aged 40-85. Among them, 2,708 had developed UC after diagnosis of ESRD. The CIR40-85 (cumulative incidence rate) of upper tract UC (UTUC) and lower tract UC (LTUC) were calculated for ESRD patients and general population, as well as SIR40-85 (standardized incidence ratio) for comparison. Results. Female ESRD patients were found to have 9-18 times of elevated risks of UC, while those of males were increased up to 4-14 times. The time trends of CIR40-84 and SIR40-84 of UTUC in females appear to decline after calendar year 2000. These trends may be related to AA associated herbal products after 1998. Conclusions. Patients with ESRD are at increased risks for both LTUC and UTUC in Taiwan. We hypothesize that the time trends associate with the consumption of aristolochic acid in Chinese herbal products (female predominant). ? 2014 Shuo-Meng Wang et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904093889&doi=10.1155%2f2014%2f149750&partnerID=40&md5=3a530312ea8edb7ed280605d298b939d https://scholars.lib.ntu.edu.tw/handle/123456789/544022 |
ISSN: | 2314-6133 | DOI: | 10.1155/2014/149750 | SDG/關鍵字: | age distribution; cancer incidence; end stage renal disease; human; national health insurance; reimbursement; review; sex difference; Taiwan; transitional cell carcinoma; adult; aged; chronic kidney failure; complication; embryology; female; male; middle aged; neoplasm; pathology; urothelium; very elderly; Adult; Aged; Aged, 80 and over; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Neoplasms; Taiwan; Urothelium |
顯示於: | 醫學系 |
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