https://scholars.lib.ntu.edu.tw/handle/123456789/544256
標題: | High incidence of and risk factors for metachronous bilateral upper tract urothelial carcinoma in Taiwan | 作者: | Huang P.-C. CHAO-YUAN HUANG SHI-WEI HUANG Lai M.-K. HONG-JENG YU Chen J. YEONG-SHIAU PU |
公開日期: | 2006 | 卷: | 13 | 期: | 7 | 起(迄)頁: | 864-869 | 來源出版物: | International Journal of Urology | 摘要: | Aim: Urothelial carcinoma (UC) can occur multifocally in the whole urothelium. A higher rate of bilateral metachronous upper tract (UT) UC was noted in Taiwan. The incidence and risk factors were largely unknown and hence were explored in the study. Methods: From January 1977 through June 2003, 462 patients with unilateral UT-UC were studied retrospectively. The cumulative incidence of contralateral recurrence was analysed with the Kaplan-Meier analysis. Potential risk factors for contralateral recurrence including age, smoking, bladder cancer, renal function, diagnostic year etc. were evaluated with the log-rank test. Independent risk factors were identified by using the Cox regression analysis. Results: The median follow-up time was 34 months (6-337). Among the 462 patients, 52 (11.3%) developed metachronous contralateral UC. The 2, 5, and 10-year contralateral disease-free survivals were 93.5%, 84.0%, and 75.7%, respectively. The median time to contralateral recurrence was 31.0 months. With the univariate analysis, only poor renal function (serum creatinine < or ?2.0 mg/dL, P < 0.001) and late diagnostic year (before or after 1990, P < 0.001) were risk factors for contralateral recurrence. In the multivariate analysis, poor renal function (hazard ratio: 2.98; 95% confidence interval: 1.67-5.33; P < 0.001) and late diagnostic year (hazard ratio: 4.27; 95% confidence interval: 1.71-10.65; P = 0.002) remained independent risk factors. Conclusions: The incidence of metachronous UT-UC is high in Taiwan. Patients who had either chronic renal insufficiency or a disease diagnosed after 1990 had a higher risk of contralateral recurrence. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745892073&doi=10.1111%2fj.1442-2042.2006.01429.x&partnerID=40&md5=428adf7c9472098a31aae8169e3a2652 https://scholars.lib.ntu.edu.tw/handle/123456789/544256 |
ISSN: | 0919-8172 | DOI: | 10.1111/j.1442-2042.2006.01429.x | SDG/關鍵字: | creatinine; adolescent; adult; aged; article; bladder cancer; cancer diagnosis; cancer incidence; cancer patient; cancer recurrence; cancer survival; confidence interval; creatinine blood level; disease free survival; female; follow up; human; Kaplan Meier method; kidney dysfunction; kidney function; log rank test; major clinical study; male; multivariate analysis; priority journal; proportional hazards model; retrospective study; risk assessment; risk factor; smoking; survival rate; Taiwan; univariate analysis; urinary tract carcinoma; urogenital tract cancer; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Disease-Free Survival; Female; Follow-Up Studies; Humans; Incidence; Kidney Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms, Second Primary; Nephrectomy; Retrospective Studies; Risk Factors; Taiwan; Ureteral Neoplasms |
顯示於: | 醫學系 |
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