https://scholars.lib.ntu.edu.tw/handle/123456789/544396
標題: | Prognostic significance of cyclin d1 polymorphisms on prostate-specific antigen recurrence after radical prostatectomy | 作者: | Yu C.-C. Lin V.C. CHAO-YUAN HUANG Liu C.-C. Wang J.-S. Wu T.T. YEONG-SHIAU PU Huang C.-H. Huang C.-N. Huang S.-P. Bao B.-Y. |
公開日期: | 2013 | 卷: | 20 | 期: | 3 SUPPL. | 起(迄)頁: | S492-S499 | 來源出版物: | Annals of Surgical Oncology | 摘要: | Background. Cyclin D1 (CCND1) is an important cellcycle regulator involved in carcinogenesis and progression of prostate cancer. We tested whether genetic variations within the CCND1 gene are related to clinical outcomes in prostate cancer patients receiving radical prostatectomy. Methods. A total of 320 clinical localized prostate cancer patients who underwent radical prostatectomy in Taiwan were prospectively follow-up in this study. A total of 5 tagged single-nucleotide polymorphisms that captured the genetic variability across the CCND1 gene were genotyped, and the prognostic significance on prostate-specific antigen (PSA) recurrence was assessed using the Kaplan- Meier analysis and Cox regression model. Results. We found a polymorphism, rs9344, and 2 haplotypes, GAGG and CTGG, consisting of rs667515, rs2450254, rs9344, and rs678653, were associated with PSA recurrence (P B 0.033). After adjusting for other clinicopathologic predictors, including age, PSA levels, pathologic stage, Gleason score, and surgical margin, rs9344 and the haplotype CTGG remained significant (P?0.044). The model based on clinical variables plus CCND1 rs9344 or haplotype showed improvement over the model without genetic information, as indicated by C7.2 % net reclassification improvement (P?0.040), integrated discrimination index (P?0.041), and likelihood ratio test (P?0.028). Conclusion. Our data suggest that the CCND1 rs9344 and a specific haplotype CTGG may be prognostic factors for PSA recurrence after radical prostatectomy. ? Society of Surgical Oncology 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892801720&doi=10.1245%2fs10434-013-2869-x&partnerID=40&md5=8fa7ad87e46b78df7d864c912a435340 https://scholars.lib.ntu.edu.tw/handle/123456789/544396 |
ISSN: | 1068-9265 | DOI: | 10.1245/s10434-013-2869-x | SDG/關鍵字: | cyclin D1; prostate specific antigen; CCND1 protein, human; cyclin D1; prostate specific antigen; tumor marker; aged; article; cancer prognosis; cancer recurrence; controlled study; follow up; genetic association; genotype; haplotype; human; major clinical study; male; prospective study; prostate cancer; prostatectomy; single nucleotide polymorphism; Taiwan; blood; cancer grading; cancer staging; genetics; Neoplasm Recurrence, Local; pathology; prognosis; Prostatic Neoplasms; single nucleotide polymorphism; Aged; Cyclin D1; Follow-Up Studies; Humans; Male; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Polymorphism, Single Nucleotide; Prognosis; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Tumor Markers, Biological |
顯示於: | 醫學系 |
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