|Title:||Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS||Authors:||Cheng J.-H.
|Keywords:||Antioxidation; Cytotoxicity; Reactive oxygen species; Xanthone||Issue Date:||2011||Journal Volume:||46||Journal Issue:||4||Start page/Pages:||1222-1231||Source:||European Journal of Medicinal Chemistry||Abstract:||
In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect. ? 2011 Elsevier Masson SAS. All rights reserved.
|Appears in Collections:||醫學系|
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