https://scholars.lib.ntu.edu.tw/handle/123456789/544427
Title: | Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS | Authors: | Cheng J.-H. Huang A.-M. Hour T.-C. Yang S.-C. YEONG-SHIAU PU Lin C.-N. |
Keywords: | Antioxidation; Cytotoxicity; Reactive oxygen species; Xanthone | Issue Date: | 2011 | Journal Volume: | 46 | Journal Issue: | 4 | Start page/Pages: | 1222-1231 | Source: | European Journal of Medicinal Chemistry | Abstract: | In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect. ? 2011 Elsevier Masson SAS. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952283054&doi=10.1016%2fj.ejmech.2011.01.043&partnerID=40&md5=ef3310a78dd5d1820c1d52767d2e67b0 https://scholars.lib.ntu.edu.tw/handle/123456789/544427 |
ISSN: | 0223-5234 | DOI: | 10.1016/j.ejmech.2011.01.043 |
Appears in Collections: | 醫學系 |
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