Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS
Journal
European Journal of Medicinal Chemistry
Journal Volume
46
Journal Issue
4
Pages
1222-1231
Date Issued
2011
Author(s)
Abstract
In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical-cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect. ? 2011 Elsevier Masson SAS. All rights reserved.
Subjects
Antioxidation; Cytotoxicity; Reactive oxygen species; Xanthone
SDGs
Other Subjects
2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid); 3 [3 (4 methylpiperazino)propoxy]xanthone; 3 [3 (cyclohexylamino)propoxy] 6 hydroxyxanthone; 3 [3 (cyclopropylamino)propoxy] 6 hydroxyxanthone; 3 [3 (diethylamino)propoxy] 6 hydroxyxanthone; 3 [3 (diethylamino)propoxy]xanthone; 3 [3 (piperazino)propoxy]xanthone; 3 [3 (piperidin 1 yl)propoxy]xanthone; 3 [3 (pyrrolidin 1 yl)propoxy]xanthone; 3 hydroxy 6 [3 (methylpiperazylamino)propoxy]xanthone; 3 hydroxy 6 [3 (piperazino)propoxy]xanthone; 3 hydroxy 6 [3 (piperidin 1 yl)propoxy]xanthone; 3 hydroxy 6 [3 (pyrrolidin 1 yl)propoxy]xanthone; allopurinol; alpha tocopherol; cisplatin; reactive oxygen metabolite; unclassified drug; xanthine oxidase; xanthone derivative; antioxidant activity; apoptosis; article; cancer cell; cell cycle arrest; cell cycle G1 phase; cell cycle progression; cell death; controlled study; drug cytotoxicity; drug potentiation; drug screening; drug structure; drug synthesis; enzyme inhibition; epithelium cell; human; human cell; IC 50; in vitro study; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cisplatin; DNA Breaks; Dose-Response Relationship, Drug; Drug Discovery; Drug Synergism; Free Radical Scavengers; Humans; Reactive Oxygen Species; Structure-Activity Relationship; Xanthones
Type
journal article