https://scholars.lib.ntu.edu.tw/handle/123456789/544429
標題: | Protective effects of plasma alpha-tocopherols on the risk of inorganic arsenic-related urothelial carcinoma | 作者: | Chung C.-J. YEONG-SHIAU PU Chen Y.-T. Su C.-T. Wu C.-C. Shiue H.-S. CHAO-YUAN HUANG Hsueh Y.-M. |
公開日期: | 2011 | 卷: | 409 | 期: | 6 | 起(迄)頁: | 1039-1045 | 來源出版物: | Science of the Total Environment | 摘要: | Arsenic plays an important role in producing oxidative stress in cultured cells. To investigate the interaction between high oxidative stress and low arsenic methylation capacity on arsenic carcinogenesis, a case-control study was conducted to evaluate the relationship among the indices of oxidative stress, such as urinary 8-hydroxydeoxyquanine (8-OHdG), as well as plasma micronutrients and urinary arsenic profiles on urothelial carcinoma (UC) risk. Urinary 8-OHdG was measured using high-sensitivity enzyme-linked immunosorbent assay kits. The urinary arsenic species were analyzed using high-performance liquid chromatography and hydride generator-atomic absorption spectrometry. Plasma micronutrient levels were analyzed using reversed-phase high-performance liquid chromatography. The present study showed a significant protective effect of plasma alpha-tocopherol on UC risk. Plasma alpha-tocopherol levels were significantly inversely related to urinary total arsenic concentrations and inorganic arsenic percentage (InAs%), and significantly positively related to dimethylarsinic acid percentage (DMA%). There were no correlations between plasma micronutrients and urinary 8-OHdG. Study participants with lower alpha-tocopherol and higher urinary total arsenic, higher InAs%, higher MMA%, and lower DMA% had a higher UC risk than those with higher alpha-tocopherol and lower urinary total arsenic, lower InAs%, lower MMA%, and higher DMA%. These results suggest that plasma alpha-tocopherol might modify the risk of inorganic arsenic-related UC. ? 2010 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751704792&doi=10.1016%2fj.scitotenv.2010.11.037&partnerID=40&md5=77582aea0b34b7e43e7dcc6c214eb0b4 https://scholars.lib.ntu.edu.tw/handle/123456789/544429 |
ISSN: | 0048-9697 | DOI: | 10.1016/j.scitotenv.2010.11.037 | SDG/關鍵字: | 8-OHdG; Arsenic concentration; Case-control study; Cultured cell; Dimethylarsinic acids; Enzyme linked immunosorbent assay; High-sensitivity; InAs; Inorganic arsenic; Methylation capacity; Micronutrient levels; Protective effects; Reversed phase high performance liquid chromatography; Urinary arsenic; Urothelial carcinoma; Absorption spectroscopy; Atomic absorption spectrometry; Indium arsenide; Liquid chromatography; Liquids; Oxidative stress; Plasmas; Semiconducting indium; Trace elements; Arsenic; 8 hydroxydeoxyguanosine; alpha tocopherol; arsenic; cacodylic acid; trace element; arsenic; carcinogen; concentration (composition); inorganic compound; methylation; plasma; trace element; adult; article; atomic absorption spectrometry; blood analysis; cancer risk; concentration (parameters); controlled study; DNA damage; enzyme linked immunosorbent assay; female; human; male; oxidative stress; priority journal; reversed phase high performance liquid chromatography; risk assessment; transitional cell carcinoma; urinalysis; alpha-Tocopherol; Antioxidants; Arsenic; Carcinogens, Environmental; Carcinoma; Case-Control Studies; DNA Damage; Female; Guanine; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; Oxidative Stress; Risk Factors; Urologic Neoplasms |
顯示於: | 醫學系 |
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