https://scholars.lib.ntu.edu.tw/handle/123456789/544450
標題: | Phloroglucinols Inhibit Chemical Mediators and Xanthine Oxidase, and Protect Cisplatin-Induced Cell Death by Reducing Reactive Oxygen Species in Normal Human Urothelial and Bladder Cancer Cells | 作者: | Lin K.-W. Huang A.-M. Tu H.-Y. Weng J.-R.U. Hour T.-C. Wei B.-L. Yang S.-C. Wang J.-P. YEONG-SHIAU PU Lin C.-N. |
關鍵字: | Antioxidant; Garcinielliptones ha-he and anti-inflammatory; NTUB1; Phloroglucinol; SV-HUC1 | 公開日期: | 2009 | 卷: | 57 | 期: | 19 | 起(迄)頁: | 8782-8787 | 來源出版物: | Journal of Agricultural and Food Chemistry | 摘要: | Phloroglucinols, garcinielliptones HA-HE (1-5), and C (6) were studied in vitro for their inhibitory effects on chemical mediators released from mast cells, neutrophils, and macrophages. Compound 6 revealed significant inhibitory effect on release of lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB). Compounds 3, 4, and 6 showed significant inhibitory effects on superoxide anion generation in rat neutrophils stimulated with (fMLP)/(CB), while compounds 1 and 5 revealed inhibitory effects on tumor necrosis factor-α (TNF-α) formation in macrophages stimulated with lipopolysaccharide (LPS). Compounds 1 and 3-6 showed inhibitory effects on xanthine oxidase (XO) and could inhibit the DNA breakage caused by O2-.. Treatment of NTUB1 with 2 to 60 μM compound 3 and 5 μM cisplatin and SV-HUC1 with 9 to 60 μM 3 and 5 μM cisplatin, respectively, resulted in an increase of viability of cells. These results indicated that compounds 1 and 3-6 showed anti-inflammatory effects and antioxidant activities. Compound 3 mediates through the suppression of XO activity and reduction of reactive oxygen species (ROS), and protection of subsequent cell death. ? 2009 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349912048&doi=10.1021%2fjf900935n&partnerID=40&md5=dc6b6d24e6a7dfb515dc1547a03c62ba https://scholars.lib.ntu.edu.tw/handle/123456789/544450 |
ISSN: | 0021-8561 | DOI: | 10.1021/jf900935n | SDG/關鍵字: | antiinflammatory agent; antioxidant; cisplatin; enzyme inhibitor; garcinielliptone; phloroglucinol; reactive oxygen metabolite; triterpene; xanthine oxidase; animal; article; bladder tumor; cell death; chemistry; drug antagonism; drug effect; enzymology; Garcinia; human; immunology; macrophage; mast cell; neutrophil; pathology; rat; tumor cell line; urothelium; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Death; Cell Line, Tumor; Cisplatin; Enzyme Inhibitors; Garcinia; Humans; Macrophages; Mast Cells; Neutrophils; Phloroglucinol; Rats; Reactive Oxygen Species; Triterpenes; Urinary Bladder Neoplasms; Urothelium; Xanthine Oxidase; Rattus |
顯示於: | 醫學系 |
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