https://scholars.lib.ntu.edu.tw/handle/123456789/544523
標題: | Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer | 作者: | Hsieh F.-I. YEONG-SHIAU PU Chern H.-D. Hsu L.-I. Chiou H.-Y. Chen C.-J. |
關鍵字: | Bladder cancer; Cigarette smoking; N-acetyltransferase 1; N-acetyltransferase 2 | 公開日期: | 1999 | 卷: | 81 | 期: | 3 | 起(迄)頁: | 537-541 | 來源出版物: | British Journal of Cancer | 摘要: | Aromatic amines from cigarette smoking or occupational exposure, recognized risk factors for bladder cancer, are metabolized by N-acetyltransferases (NAT). This study examined the association of (NAT) 1 and 2 genotypes with the risk of smoking-related bladder cancer. A total of 74 pathoiogically confirmed bladder cancer patients and 184 controls were serially recruited from the National Taiwan University Hospital. History of cigarette smoking and other risk factors for bladder cancer was obtained through standardized questionnaire interview. Peripheral blood lymphocytes were collected from each subject and genotyped for NAT1 and NAT2 by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods. Allele frequency distributions of NAT1 and NAT2 were similar between cases and controls. There was a significant dose-response relationship between the risk of bladder cancer and the quantity and duration of cigarette smoking. The biological gradients were significant among subjects carrying NAT1*10 allele or NAT2 slow acetylators, but not among NAT2 rapid acetylators without NAT1*10 allele. The results are consistent with the hypothesis that NAT1 and NAT2 might modulate the susceptibility to bladder cancer associated with cigarette smoking. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032837276&doi=10.1038%2fsj.bjc.6690727&partnerID=40&md5=513996f5af41676ebb6aae6c9f6b2190 https://scholars.lib.ntu.edu.tw/handle/123456789/544523 |
ISSN: | 0007-0920 | DOI: | 10.1038/sj.bjc.6690727 | SDG/關鍵字: | acyltransferase; aromatic amine; acetylator phenotype; article; bladder cancer; cancer risk; cigarette smoking; controlled study; DNA sequence; dose response; gene frequency; genetic polymorphism; genotype; human; interview; major clinical study; metabolism; occupational exposure; peripheral lymphocyte; priority journal; questionnaire; university hospital; Acetylation; Aged; Alleles; Arylamine N-Acetyltransferase; Biotransformation; Carcinoma, Transitional Cell; Chromosomes, Human, Pair 8; Female; Genetic Predisposition to Disease; Genotype; Humans; Isoenzymes; Male; Middle Aged; Odds Ratio; Plants, Toxic; Polymorphism, Restriction Fragment Length; Risk Factors; Smoking; Taiwan; Time Factors; Tobacco; Urinary Bladder Neoplasms |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。